White House announces plans to reduce prescription drug abuse
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President Barack Obama’s administration unveiled on Tuesday a plan to fight what it calls a prescription drug abuse epidemic.
Between 2002 and 2009, the number of Americans aged 12 and older abusing pain relievers increased by 20 percent, according to the Substance Abuse and Mental Health Services Administration.
“Unintentional drug overdose is a growing epidemic in the U.S. and is now the leading cause of injury death in 17 states,” Center for Disease Control Director Dr. Thomas Frieden was quoted as saying in a statement from the White House’s Office of National Drug Control Policy.
Breastfeeding tied to stronger maternal response to baby’s cry
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A new study from the Journal of Child Psychology and Psychiatry finds that mothers who feed their babies breast milk exclusively, as opposed to formula, are more likely to bond emotionally with their child during the first few months after delivery. The breastfeeding mothers surveyed for the study showed greater responses to their infant’s cry in brain regions related to caregiving behavior and empathy than mothers who relied upon formula as the baby’s main food source. This is the first paper to examine the underlying neurobiological mechanisms as a function of breastfeeding, and to connect brain activity with maternal behaviors among human mothers.
The fMRI-based findings suggest that breastfeeding and factors associated with breastfeeding, such has high levels of hormones (oxytocin, prolactin), stress, and culture may all play an important role for mothers’ brain activity and parenting behaviours during the early postpartum period. The research shows that up to three or four months after delivery some of the brain regions originally observed at one month postpartum (amygdala, putamen, globus pallidus, and superior frontal gyrus) continued to activate and were correlated with maternal, sensitive behavior among the same group of mothers.
The findings highlight the dramatic relationship between breastfeeding, brain activity and parenting behaviours during the early postpartum period.
Spring-cleaning the mind?
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Lapses in memory occur more frequently with age, yet the reasons for this increasing forgetfulness have not always been clear. According to new research from Concordia University, older individuals have reduced learning and memory because their minds tend to be cluttered with irrelevant information when performing tasks. Published in The Quarterly Journal of Experimental Psychology, these findings offer new insights into why ageing is associated with a decline in memory and may lead to practical solutions.
“The first step of our study was to test the working memory of a younger and older population and compare the results,” says Mervin Blair, first author and a PhD student in Concordia’s Department of Psychology and a member at the Centre for Research in Human Development. “In our study, working memory refers to the ability of both retaining and processing information.”
Some 60 participants took part in the study: half were an average of 23 years old, while the other half was about 67 years old. Each participant was asked to perform a working memory task, which included recalling and processing different pieces of information.
Blood Test Could Predict Metastasis Risk in Melanoma
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Scientists at Yale University have identified a set of plasma biomarkers that could reasonably predict the risk of metastasis among patients with melanoma, according to findings published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
“The rate at which melanoma is increasing is dramatic, and there is a huge number of patients under surveillance,” said Harriet Kluger, M.D., associate professor of medicine at Yale University School of Medicine. “Our current method of surveillance includes periodic imaging, which creates huge societal costs.”
Melanoma is the fifth most common cancer in men and the seventh most common cancer in women. It is estimated that 68,130 people in the United States were diagnosed in 2010, and 8,700 died. With proper screening, melanoma can often be caught early enough to be removed with surgery, and mortality typically comes when the cancer metastasizes. The risk of metastasis varies from less than 10 percent for those with stage 1A melanoma, to as high as 70 percent with stage 3C.
A cancer marker and treatment in 1?
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Researchers at the University of California, San Diego School of Medicine say antibodies to a non-human sugar molecule commonly found in people may be useful as a future biomarker for predicting cancer risk, for diagnosing cancer cases early and, in sufficient concentration, used as a treatment for suppressing tumor growth.
The work was led by Richard Schwab, MD, assistant clinical professor of medicine, and Ajit Varki, MD, professor of medicine and cellular and molecular medicine, with other faculty at the UCSD Moores Cancer Center and the UCSD Glycobiology Research and Training Center. Collaborators include researchers from the groups of Xi Chen at UC Davis, Inder Verma at the Salk Institute and scientists from Sialix, Inc., a biotechnology company based in Vista, CA.
It is published in the April 19 online issue of the journal Cancer Research and in the May 1 print edition.
Obama to Republicans: ‘You think we’re stupid?’
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President Barack Obama said he challenged Republicans to try to repeal his landmark healthcare reform in private budget talks last week, taunting his opponents with a question: “You think we’re stupid?”
In one of three political fund-raisers for his re-election campaign on Thursday night, Obama spoke candidly to supporters about the closed-door White House conversations that led to a deal that barely avoided a shutdown of the U.S. government.
He said he warned Republicans he would veto any legislation passed by Congress that sought to defund his 2010 healthcare overhaul. Republicans, who took control of the U.S. House of Representatives later that year, had vowed to kill the law.
Rising star of brain found to regulate circadian rhythms
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The circadian system that controls normal sleep patterns is regulated by a group of glial brain cells called astrocytes, according to a study published online on April 14th in Current Biology, a Cell Press publication. Neuroscientists from Tufts University School of Medicine found that disruption of astrocyte function in fruit flies (Drosophila) led to altered daily rhythms, an indication that these star-shaped glial cells contribute to the control of circadian behavior. These results provide, for the first time, a tractable genetic model to study the role of astrocytes in circadian rhythms and sleep disorders.
According to the National Institute of Neurological Disorders and Stroke, more than 40 million Americans suffer from sleep disorders. Some sleep disorders arise from changes to the internal clock that is modulated by environmental signals, including light. Biologically, the internal clock is known to be composed of a network of neurons that controls rhythmic behaviors. Rob Jackson and his team previously had found that normal circadian rhythms require a glial-specific protein. In the new study, the team demonstrates that glia, and particularly astrocytes, are active cellular elements of the neural circuit that controls circadian rhythms in the adult brain.
“This is significant because glia have been traditionally viewed as support cells rather than independent elements that can regulate neurons and behavior. Neurons have had center stage for some time but current research is establishing the role of glial cells in brain function,” said Rob Jackson, PhD, professor of neuroscience at Tufts University School of Medicine (TUSM) and member of the genetics and neuroscience program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts. Jackson is also the director of the Center for Neuroscience Research (CNR) at TUSM.
Minimally invasive thyroid surgery effective in children
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Surgical approaches that reduce incision size and recovery time from thyroid surgery work well in children, physician-scientists report.
“It brings parents comfort to know it’s going to be a small incision, an outpatient surgery with no drains or staples on the skin. We just use some glue for the skin and the recovery is very rapid,” said Dr. David Terris, Chairman of the Department of Otolaryngology-Head and Neck Surgery at Georgia Health Sciences University.
The results should bring comfort as well with complication rates of minimally invasive thyroid surgery on par with the standard surgical approach that can leave a several-inch scar at the base of the neck. Terris and Dr. Melanie W. Seybt, endocrine-head and neck surgeon at GHSU, co-authored the study published in Annals of Otology, Rhinology and Laryngology.
Periodontal stem cell transplantation shows promise
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Periodontal ligament stem cells (PDLSCs) have been found to be the most efficacious of three kinds of clinically tested dental tissue-derived stem cells, reports a study published in the current issue of Cell Transplantation (20:2), freely available on-line.
According to researchers in Seoul, South Korea, transplantation of PDLSCs into beagle dogs modeled with advanced periodontal (gum) disease that affected their premolars and molars, which are morphologically similar to the corresponding areas in human dentition, was most effective. PDLSCs showed the best regenerating capacity of the periodontal ligament (which attaches the tooth to the alveolar bone in which the teeth sit), alveolar bone, cementum (material that comprises the surface of a tooth’s root), peripheral nerve and blood vessels when compared to similar transplants using dental pulp stem cells (taken from the center of teeth) or periapical follicular stem cells (taken from the developing root).
“Periodontitis, characterized by bone resorption, periodontal pocketing and gingival inflammation, is the most common cause of tooth loss in adults and affects 10 to 15 percent of adults worldwide,” said corresponding author Dr. Pill-Hoon Choung of the Seoul National University School of Dentistry. “Our study sought to evaluate the effectiveness of autologous stem cell transplantation (i.e. transplant of a patient’s own cells) using three kinds of autologous dental stem cells similar to mensenchymal stem cells.”
Clinical study suggests estrogen levels and breast health can be altered
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Researchers from Canada and the United States today told attendees of the Experimental Biology 2011 Scientific Meeting that they have uncovered a possible means of enabling women to favorably influence whether the estrogens in their bodies take a “beneficial path” or a “disease-potential” path.
The researchers tested a nutritional combination of indole-3 carbinol, milk thistle extract, calcium-D-glucarate, Schizandra chinensis fruit extract, stinging nettle, lignans extracted from the Norway spruce, and vitamin D on 47 pre-menopausal women and 49 post-menopausal women for 28 days. On day one and 28, they analyzed blood and urine samples. Researchers were pleasantly surprised to discover consumption of the femMED supplement significantly increased the mean urinary concentration of 2-OHE in pre- and post-menopausal women (by 110% and 88%, respectively), suggesting a risk-reducing effect. The Breast Health supplement was well-tolerated, and displayed no adverse side effects.
Dr. Cathleen London, MD said, “Although the trial was small it was well designed and well conducted. Importantly, we know that cruciferous vegetables, fish oil, and lignans from flax and nuts are all thought to support healthy metabolism of estrogens, but people do not eat enough fresh cruciferous vegetables in their diet, making nutritional supplementation a viable option. Although this is a preliminary study, it adds to our scientific knowledge about the role of estrogens and their metabolism in the breast health of pre-menopausal and post-menopausal women.” Dr. London was not involved with this project.
Atherosclerotic plaques formed during a late and limited time period in life
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In a new study performed in humans, researchers from Karolinska Institutet have determined the age of atherosclerotic plaques by taking advantage of Carbon-14 (14C) residues in the atmosphere, prevailing after the extensive atomic bomb tests in the 50ties and 60ties. The findings, published in the scientific online journal PLoS ONE, suggest that in most people plaque formation occurs during a relatively short and late time period in life of 3-5 years.
The investigators collected carotid plaques during carotid stenosis surgery at the Stockholm South General Hospital (Södersjukhuset). The patients were admitted for surgery since their carotid lesions partly obstructed the blood flow to the brain, causing symptoms of insufficient oxygen called Trans Ischemic Attacks (TIA) that in some cases also had lead to strokes.
The plaques were carbon dated at Uppsala University, by using Accelerator Mass Spectrometry (AMS). As a result of the extensive atomic bomb test in the 50-ties and 60-ties, the atmospheric concentration of 14C rapidly increased. Since then the concentration of 14C is declining, which now can be used to determine the time of synthesis of any biological sample.
Is beauty found in the whites of the eyes? ‘Red eyes’ associated with the sad and unattractive
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Beauty is said to be in the eye of the beholder, but a new study reveals that the reverse is also true; unattractiveness is in the eye of the beheld. Research published in Ethology finds that people with bloodshot eyes are considered sadder, unhealthier and less attractive than people whose eye whites are untinted, a cue which is uniquely human.
“Red, ‘bloodshot’ eyes are prominent in medical diagnoses and in folk culture”, said lead author Dr. Robert R. Provine from the University of Maryland, Baltimore County. “We wanted to know if they influence the everyday behaviour and attitudes of those who view them, and if they trigger perceptions of attractiveness.”
Bloodshot eyes occur when the small blood vessels of the usually transparent conjunctiva membrane on the surface of the eye become enlarged and congested with blood, giving a red tint to the underlying sclera, the “white” of the eyes. Redness of the sclera is believed to be a general but important sign of a person’s emotional and biological state.
Scientists call for new atomic risk strategy
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New ways need be found to communicate to the public the true risks of radiation from crises like the one at Japan’s Fukushima nuclear plant without fanning overblown fears of an “apocalypse,” scientists say.
Communication has to get across statistics about risks and at the same time address peoples’ real fears, especially when they concern atomic power which has associations with the Cold War and the 1945 bombings of Hiroshima and Nagasaki.
Many experts say Japan’s March 11 tsunami, which has so far left 28,000 people dead or missing, is likely to have a greater impact on public health in Japan than radiation leaking from the stricken plant.
Social isolation, stress-induced obesity increases breast cancer risk in mice
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Stress from social isolation, combined with a high-fat diet, increases levels of a brain neurotransmitter – neuropeptide Y, or NPY – in mice that then promotes obesity, insulin resistance, and breast cancer risk, say researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center (GUMC).
Major increases in NPY levels are seen when isolation and the high fat diet are combined. Still, the mice that were isolated for two weeks and fed a control diet had elevated NPY levels and increased terminal end buds, a structure in the mammary gland where mammary cancers form.
The researchers say their findings, reported at the American Association for Cancer Research (AACR) 102nd Annual Meeting 2011, appear to link a number of findings in humans, such as the fact that social isolation is associated with an increased risk of cancer development and mortality, and that obesity is a risk factor for breast cancer.”
New tool helps surgeons predict patients’ risk of complications after bariatric operations
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A new risk calculator can predict the risk of postoperative complications occurring for individual bariatric surgery patients, according to a study published in the March issue of the Journal of the American College of Surgeons. The risk calculator will help in surgical decision-making and will help patients better understand what they can expect during recovery in order to prepare for a bariatric operation.
The study authors developed the risk calculator based on data from the American College of Surgeons’ National Surgical Quality Improvement Program (ACS NSQIP), which collected pre-operative through 30-day follow up data on patients undergoing an operation at 183 (year 2007) and 211 (year 2008) participant academic and community hospitals. Bariatric surgical procedures have proven successful in treating obesity and particularly in addressing related co-morbidities such as diabetes, hypertension, and sleep apnea. While the epidemic of obesity continues to plague America, its highly effective surgical therapy is underutilized due to concerns for surgical risk among patients and referring physicians.
The 2007 ACS NSQIP data used to develop the risk calculator included 11,023 patients, all undergoing bariatric procedures for morbid obesity. The 2008 dataset was used for validation. Recent heart attack or angina, stroke, high blood pressure, use of blood thinners, limited ability to perform basic activities of daily living, higher weight and the type of bariatric procedure, were found to be associated with increased risk.
