Scientists prove regular aspirin intake halves cancer risk
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Scientists including those from Queen’s University have discovered that taking regular aspirin halves the risk of developing hereditary cancers.
Hereditary cancers are those which develop as a result of a gene fault inherited from a parent. Bowel and womb cancers are the most common forms of hereditary cancers. Fifty thousand people in the UK are diagnosed with bowel and womb cancers every year; 10 per cent of these cancers are thought to be hereditary.
The decade-long study, which involved scientists and clinicians from 43 centres in 16 countries and was funded by Cancer Research UK, followed nearly 1,000 patients, in some cases for over 10 years. The study found that those who had been taking a regular dose of aspirin had 50 per cent fewer incidences of hereditary cancer compared with those who were not taking aspirin.
The research focused on people with Lynch syndrome which is an inherited genetic disorder that causes cancer by affecting genes responsible for detecting and repairing damage in the DNA. Around 50 per cent of those with Lynch syndrome develop cancer, mainly in the bowel and womb. The study looked at all cancers related to the syndrome, and found that almost 30 per cent of the patients not taking aspirin had developed a cancer compared to around 15 per cent of those taking the aspirin.
China arrests 18 in illegal transplant crackdown
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Police in eastern China have arrested 18 people after a raid on two clinics offering illegal organ transplants, state news agency Xinhua reported on Wednesday.
The clinics in Jinan, Shandong’s provincial capital, were raided on Sunday as doctors were preparing a kidney transplant, Xinhua cited local police as saying.
“Police were tipped off earlier this month, and then launched a probe with the city’s health bureau against the two clinics. They found that vehicles and people regularly shuttled between the two clinics, which were not far away from each other,” the report said.
Preventing cancer development inside the cell cycle
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Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have identified a cell cycle-regulated mechanism behind the transformation of normal cells into cancerous cells. The study shows the significant role that protein networks can play in a cell leading to the development of cancer. The study results, published in the October 21 issue of the journal Molecular Cell, suggest that inhibition of the CK1 enzyme may be a new therapeutic target for the treatment of cancer cells formed as a result of a malfunction in the cell’s mTOR signaling pathway.
In the study, NYU Cancer Institute researchers examined certain multi-protein complexes and protein regulators in cancer cells. Researchers identified a major role for the multi-protein complex called SCFβTrCP . It assists in the removal from cancer cells the recently discovered protein DEPTOR, an inhibitor of the mTOR pathway. SCF (Skp1, Cullin1, F-box protein) ubiquitin ligase complexes are responsible for the removal of unnecessary proteins from a cell. This degradation of proteins by the cell’s ubiquitin system controls cell growth and prevents malignant cell transformation. Researchers show that inhibiting the ability of SCFβTrCP to degrade DEPTOR in cells can result in blocking the proliferation of cancer cells. In addition, researchers discovered that the activity of CK1 (Casein Kinase 1), a protein that regulates signaling pathways in most cells, is needed for SCFβTrCP to successfully promote the degradation of DEPTOR.
“Low levels of DEPTOR and high levels of mTOR activity are found in many cancers, including cancers of the breast, prostate, and lung,” said senior study author Michele Pagano, MD, the May Ellen and Gerald Jay Ritter Professor of Oncology and Professor of Pathology at NYU Langone Medical Center and a Howard Hughes Medical Institute Investigator. “It is critical for researchers to better understand how the protein DEPTOR is regulated. Our study shows it would be advantageous to increase the levels of DEPTOR in many types of cancer cells to inhibit mTOR and prevent cell proliferation.”
What you want versus how you get it
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New research reveals how we make decisions. Birds choosing between berry bushes and investors trading stocks are faced with the same fundamental challenge - making optimal choices in an environment featuring varying costs and benefits. A neuroeconomics study from the Montreal Neurological Institute and Hospital – The Neuro, McGill University, shows that the brain employs two separate regions and two distinct processes in valuing ‘stimuli’ i.e. ‘goods’ (for example, berry bushes), as opposed to valuing the ‘actions,’ needed to obtain the desired option (for example flight paths to the berry bushes). The findings, published in the most recent issue of the Journal of Neuroscience and funded by the Canadian Institutes of Health Research, are vital not only for improving knowledge of brain function, but also for treating and understanding the effects of frontal lobe damage, which can be a feature of common neurological conditions ranging from stroke to traumatic brain injury to dementia.
Decision making - selecting the most valuable option, typically by taking an action - requires value comparisons, but there has been debate about how these comparisons occur in the brain: is value linked to the object itself , or to the action required to get that object. Are choices made between the things we want, or between the actions we take? The dominant model of decision making proposes that value comparisons occur in series, with stimulus value information feeding into actions (the body’s motor system). “So, in this study we wanted to understand how the brain uses value information to make decisions between different actions, and between different objects,” said the study’s lead investigator Dr. Lesley Fellows, neurologist and researcher at The Neuro. “The surprising and novel finding is that in fact these two mechanisms of choice are independent of one another. There are distinct processes in the brain by which value information guides decisions, depending on whether the choice is between objects or between actions.” Dr. Fellows often sees patients with damage to the frontal lobe, where decision making areas of the brain are located. “This finding gives me more insight into what is happening in the brain of my patients, and may lead to new treatments and new ways to care for them and manage their symptoms.”
“Despite the ubiquity and importance of decision making, we have had, until now, a limited understanding of its basis in the brain,” said Fellows. “Psychologists, economists, and ecologists have studied decision making for decades, but it has only recently become a focus for neuroscientists.
Can aromatherapy produce harmful indoor air pollutants?
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Spas that offer massage therapy using fragrant essential oils, called aromatherapy, may have elevated levels of potentially harmful indoor air pollutants such as volatile organic compounds (VOCs) and ultrafine particles, according to an article in Environmental Engineering Science, a peer-reviewed journal published by Mary Ann Liebert, Inc.. The article is available free online at http://www.liebertpub.com/ees
Fragrant essential oils, derived from plants, may release various VOCs into the air. VOC degradation caused by the reaction of these compounds with ozone present in the air can produce small, ultrafine byproducts called secondary organic aerosols (SOAs), which may cause eye and airway irritation.
Taiwanese researchers Der-Jen Hsu (National Kaohsiung First University of Science and Technology), Hsiao-Lin Huang (Chia-Nan University of Pharmacy and Science, Tainan), and Shiann-Cherng Sheu (Chang-Jung Christian University, Tainan) tested both fragrant and Chinese herbal essential oils for SOA formation in a controlled-environment study chamber under different test conditions. They also performed air sampling and analysis in spa centers that offer massage therapy using essential oils.
Study links pollutants to a 450 percent increase in risk of birth defects
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Pesticides and pollutants are related to an alarming 450 percent increase in the risk of spina bifida and anencephaly in rural China, according to scientists at The University of Texas at Austin and Peking University.
Two of the pesticides found in high concentrations in the placentas of affected newborns and stillborn fetuses were endosulfan and lindane. Endosulfan is only now being phased out in the United States for treatment of cotton, potatoes, tomatoes and apples. Lindane was only recently banned in the United States for treatment of barley, corn, oats, rye, sorghum and wheat seeds.
Strong associations were also found between spina bifida and anencephaly and high concentrations of polycyclic aromatic hydrocarbons (PAHs), which are byproducts of burning fossil fuels such as oil and coal. Spina bifida is a defect in which the backbone and spinal canal do not close before birth. Anencephaly is the absence of a large part of the brain and skull.
Fatal Crashes in the U.S.: Fewer Canadian Drivers Under The Influence
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A new study by researchers at the Johns Hopkins Center for Injury Research and Policy and Columbia University finds alcohol-related fatal motor vehicle crashes in the U.S. are much lower among drivers with Canadian licenses than drivers with U.S. or Mexican licenses. The prevalence of alcohol involvement in fatal crashes was 27 percent for both U.S. and Mexican drivers, and 11 percent for Canadian drivers. Similarly, alcohol impairment was found in 23 percent of U.S. and Mexican drivers and 8 percent of Canadian drivers involved in a fatal crash. Research from other countries finds foreign drivers are at greater risk of crashes than native drivers. In contrast, this study shows that drivers licensed in Mexico and Canada who were involved in fatal crashes in the U.S. had the same or less alcohol impairment than U.S.-licensed drivers. The report is published in the October issue of Injury Prevention and is available on the journal’s website.
“Our findings were unexpected, partly because the substantial cultural differences between the U.S. and Mexico led us to anticipate differences in alcohol-related crashes,” said lead study author Susan P. Baker, a professor with the Johns Hopkins Center for Injury Research and Policy, part of the Johns Hopkins Bloomberg School of Public Health. “We also anticipated that Canadian drivers in U.S. crashes would be similar to U.S. drivers because the rate of alcohol-related fatal crashes is similar within the two countries.” Together, Mexican and Canadian drivers comprise more than 70 percent of all foreign-licensed drivers involved in fatal crashes in the U.S.
As a possible explanation, the researchers speculate that the less prominent role of alcohol in fatal crashes of Canadian-licensed drivers in the U.S. may suggest that a larger proportion of Canadians were traveling on vacation or business, situations that may be less likely to involve alcohol. Crashes at night (when alcohol is more likely to be involved) were also least common among Canadian-licensed drivers. And finally, it is also possible that Canadians are less likely to drive after drinking.
China vaccinates 4.5 million people in fight against polio
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China vaccinated 4.5 million children and young adults over the last five weeks in the western region of Xinjiang in a fight against polio after the disease paralyzed 17 people and killed one of them, the World Health Organization said.
Polio has broken out in China for the first time since 1999 and scientists say the strain originated from Pakistan. The outbreak marked the latest setback to a global campaign to eradicate polio, now endemic in only four countries—Afghanistan, India, Pakistan and Nigeria.
“Even if they don’t come down with any symptoms (carriers), by giving them polio vaccine we make that person less infectious,” said Oliver Rosenbauer, WHO spokesman for the Global Polio Eradication Initiative in Geneva.
Eating your greens can change the effect of your genes on heart disease, say researchers
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A long-held mantra suggests that you can’t change your family, the genes they pass on, or the effect of these genes. Now, an international team of scientists, led by researchers at McMaster and McGill universities, is attacking that belief.
The researchers discovered the gene that is the strongest marker for heart disease can actually be modified by generous amounts of fruit and raw vegetables. The results of their study are published in the current issue of the journal PLoS Medicine.
“We know that 9p21 genetic variants increase the risk of heart disease for those that carry it,” said Dr. Jamie Engert, joint principal investigator of the study, who is a researcher in cardiovascular diseases at the Research Institute of the McGill University Health Centre (RI-MUHC) and associate member in the Department of Human Genetics at McGill University. “But it was a surprise to find that a healthy diet could significantly weaken its effect.”
Child abuse in birds: Study documents ‘cycle of violence’ in nature
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For one species of seabird in the Galápagos, the child abuse “cycle of violence” found in humans plays out in the wild.
The new study of Nazca boobies by Wake Forest University researchers provides the first evidence from the animal world showing those who are abused when they are young often grow up to be abusers. The study appears in the October issue of the ornithology journal, The Auk.
“We were surprised by the intense interest that many adults show in unrelated young, involving really rough treatment,” said Wake Forest Professor of Biology Dave Anderson, who led the study with Wake Forest graduate student Martina Müller. “A bird’s history as a target of abuse proved to be a strong predictor of its adult behavior.”
