Cancer
CSHL scientists identify new drug target against virulent type of breast cancer
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Tumor cells in a particular subset of breast cancer patients churn out too much of a protein called ErbB2—also often called HER2—which drives the cells to proliferate unchecked. Patients unlucky enough to be in this group—about one in four—have poorer prognoses and clinical outcomes than those who don’t.
The drugs Herceptin and Lapatinib, prescribed in combination with other chemotherapeutic agents, have improved this picture significantly, but leave plenty of room for improvement: they suppress ErbB2 but are effective against less than half of ErbB2-producing tumors. Moreover, patients with tumors that do respond usually develop resistance to these drugs.
A team of scientists at Cold Spring Harbor Laboratory has just published research identifying an enzyme called Brk that may serve as a target for future drugs developed to fight ErbB2-positive tumors. Brk, they report, helps these tumors become virulent and is also implicated in the process through which the tumors develop drug resistance.
Low cholesterol associated with cancer in diabetics
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Low levels of LDL cholesterol as well as high levels are associated with cancer in patients with type 2 diabetes, found a prospective cohort study http://www.cmaj.ca/press/pg427.pdf published in CMAJ.
Researchers from the Hong Kong Institute of Diabetes and Obesity, the Li Ka Shing Institute of Health Sciences and The Chinese University of Hong Kong conducted a study of 6107 Chinese patients with type 2 diabetes and found a V-shaped risk relation between LDL cholesterol and cancer in patients not receiving statin therapy.
“LDL cholesterol levels below 2.80 mmol/L and levels of at least 3.90 mmol/L were both associated with markedly elevated risk of cancer among patients who did not use statins,” state Dr. Juliana Chan and coauthors.
Women exposed to negative life events at greater risk of breast cancer: BGU study
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Happiness and optimism may play a role against breast cancer while adverse life events can increase the risk of developing the disease, according to a study by Professor Ronit Peled, at Ben-Gurion University of the Negev in Israel. An article on the study titled “Breast Cancer, Psychological Distress and Life Events among Young Women,” was just published in the British journal BMC Cancer (8:245, August 2008).
In the study, researchers questioned women about their life experiences and evaluated their levels of happiness, optimism, anxiety, and depression prior to diagnosis. Researchers used this information to examine the relationship between life events, psychological distress and breast cancer among young women.
A total of 622 women between the ages of 25 and 45 were interviewed: 255 breast cancer patients and 367 healthy women. “The results showed a clear link between outlook and risk of breast cancer, with optimists 25 percent less likely to have developed the disease. Conversely, women who suffered two or more traumatic events had a 62 percent greater risk,” Peled said. “Young women who have been exposed to a number of negative life events should be considered an ‘at-risk’ group for breast cancer and should be treated accordingly.”
Stem cell test to help treat bowel cancer
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Stem cell scientists have developed a new and more accurate way of spotting aggressive forms of bowel cancer, allowing for tailored treatment that should improve patients’ chances of survival.
British researchers said on Wednesday those with the most aggressive kind of cancer could be identified early by testing for a stem cell marker protein called Lamin A.
The team concluded that patients testing positive for Lamin A should be given chemotherapy, in addition to surgery, to increase their chances of survival.
Physical activity may lessen kidney cancer risk
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Being active during adolescence and in adulthood appears to reduce the likelihood of developing kidney cancer later in life, a study shows.
Dr. Steven C. Moore of the National Cancer Institute in Bethesda, Maryland and colleagues analyzed data on nearly half a million people aged 50 to 71 who responded to a survey about their diet and level of physical activity, currently and in their teen years.
The study collected reports on how often during the previous year participants obtained 20 minutes of strenuous exercise; their current level of sitting, walking, standing, climbing stairs and doing heavy work during routine daily activities; and the physical activities they engaged in when 15 to 18 years old.
Racial differences again seen in prostate cancer
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Black men with prostate cancer, compared with their White counterparts, have a poorer prognosis that is not fully explained by other “co-morbid” illnesses, or by different screening rates or access to healthcare, researchers from the UK report.
The finding stems from a systematic review and pooled analysis of 48 published studies that reported Black-White differences in prostate cancer prognosis.
“Some of the differences in prostate cancer mortality may reflect less aggressive management amongst Black men, particularly in older cohorts,” Dr. Yoav Ben-Shlomo from the University of Bristol and colleagues suggest in a report in the International Journal of Cancer.
Checking more lymph nodes linked to cancer patient survival
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Why do patients with gastric or pancreatic cancer live longer when they are treated at cancer centers or high-volume hospitals than patients treated at low-volume or community hospitals?
New research from Northwestern University’s Feinberg School of Medicine found that cancer patients have more lymph nodes examined for the spread of their disease if they are treated at hospitals performing more cancer surgeries or those designated as comprehensive cancer centers.
Lymph node metastases (indicating the spread of cancer) have been shown to predict patients’ prognosis after cancer tissue is removed from the stomach or pancreas. If too few lymph nodes are examined for malignant cells, a patient’s cancer may be incorrectly classified, which alters the prognosis, treatment decisions and eligibility for clinical trials.
Has Cancer Spread? Research Identifies Best Way to Find Answers
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For patients with head and neck cancer, accurately determining how advanced the cancer is and detecting secondary cancers usually means undergoing numerous tests - until now. New Saint Louis University research has found that the PET-CT scanner can be used as a stand-alone tool to detect secondary cancers, which occur in 5 to 10 percent of head and neck cancer patients.
The study findings, which were presented on Tuesday, July 22, at the 7th International Conference on Head and Neck Cancer in San Francisco, Calif., will streamline care for head and neck cancer patients allowing them to begin treatment earlier, says Michael Odell, M.D., assistant professor of otolaryngology at Saint Louis University School of Medicine.
“There has been a lot of confusion about the best ways to evaluate head and neck cancer patients to see if their cancer has spread,” said Odell, the study’s primary author.
“Emotional” writing may help ease cancer pain
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Some cancer patients may find that putting their emotions down in writing helps improve their pain and general well-being, a study suggests.
Such writing, part of a concept called “narrative” medicine, has been seen as a way to aid communication between seriously ill patients and their doctors.
But the act of writing, itself, may also help patients better understand themselves and their needs, according to the study team, led by Dr. M. Soledad Cepeda of Tufts-New England Medical Center in Boston.
Computer Predicts Anti-Cancer Molecules
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A new computer-based method of analyzing cellular activity has correctly predicted the anti-tumour activity of several molecules. Research published today in BioMed Central’s open access journal, Molecular Cancer, describes ‘CoMet’ – a tool that studies the integrated machinery of the cell and predicts those components that will have an effect on cancer.
Jeffery Skolnick, professor in the School of Biology and director of the Center for the Study of Systems Biology, in collaboration with John McDonald, chair of the School of Biology, led a team from the Georgia Institute of Technology who have developed this new strategy.
“This opens up the possibility of novel therapeutics for cancer and develops our understanding of why such metabolites work. CoMet provides a deeper understanding of the molecular mechanisms of cancer,” said Skolnick.
Obesity ups a woman’s pancreatic cancer risk: study
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Obese women who carry most of their extra weight around the stomach are 70 percent more likely to develop pancreatic cancer, an international team of researchers reported on Tuesday.
The findings suggest are some of the first evidence that the link between obesity and pancreatic cancer is as strong in women as in men, Juhua Luo of Sweden’s Karolinska Institute and colleagues reported in the British Journal of Cancer.
“We found that the risk of developing pancreatic cancer was significantly raised in obese postmenopausal women who carry most of their excess weight around the stomach,” she said in a statement.
Smoking linked to decrease in uterine cancer risk
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Cigarette smoking appears to be associated with a decreased risk of cancer of the endometrium, the inner lining of the uterus, research from China suggests.
“The benefit of smoking was observed almost exclusively in postmenopausal women and not in premenopausal women,” principal investigator Dr. Bin Wang of Nanjing Medical University told Reuters Health.
However, in spite of this link, “cigarette smoking could dramatically increase the incidence of many other chronic diseases,” Wang pointed out.
Breast Asymmetry After Cancer Treatment Affects Quality of Life
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Most women with breast cancer assume that surgery to preserve their breast will be less disfiguring than a mastectomy that removes the entire breast.
But nearly one-third of women reported pronounced asymmetry between their breasts, and that perceived disfigurement greatly affects a woman’s quality of life after treatment, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
The researchers found that compared to women with little to no breast asymmetry, women whose affected breast looked significantly different were twice as likely to fear their cancer recurring and to have symptoms of depression. These women were also more likely to perceive themselves as less healthy and to feel stigmatized by their breast cancer treatment.
New fertility technique targets women with cancer
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A new technique may help newly diagnosed cancer patients preserve their eggs, and perhaps their fertility, before chemotherapy, German researchers said on Monday.
Currently, many women collect and freeze some of their eggs to try to have children after their cancer treatment, which can make them infertile. The process can take up to six weeks.
However, if a cancer diagnosis comes at the start of the menstrual cycle, many women are unable to delay chemotherapy and preserve their eggs, Michael Von Wolf told the European Society of Human Reproduction and Embryology.
Cells in blood may help cancers spread: US study
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Normal cells in the blood that play a role in healing wounds may also be creating the right conditions for cancer cells to spread, U.S. researchers said on Tuesday.
They said fibrocytes, blood cells derived from bone marrow, could explain how healthy cells become habitats for cancer.
“Cancer cells do not enter healthy tissue easily. We know that,” Dr. Hendrik van Deventer of the University of North Carolina at Chapel Hill, whose research appears in the American Journal of Pathology, said in a telephone interview.
