Endocrinology
Spray-on estrogen relieves hot flushes
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A form of estrogen, estradiol, sprayed on the skin is a safe, effective, and convenient way for post-menopausal women to relieve hot flushes, a study shows.
Evamist, which is marketed by Ther-Rx Corporation, is the first transdermal estradiol spray to be approved by the US Food and Drug Administration for treating moderate-to-severe menopausal symptoms in healthy women, according to the report in the medical journal Obstetrics & Gynecology.
“This estradiol ‘spray-on-patch’ is a treatment option for women who will benefit from the advantages of transdermal estradiol delivery but are intolerant of or are not inclined to use patches, gels, or emulsions,” write Dr. John E. Buster, from Brown University in Providence, Rhode Island, and colleagues.
Many Men With Low Testosterone Levels Do Not Receive Treatment
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The majority of men with androgen deficiency may not be receiving treatment despite having sufficient access to care, according to a report in the May 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Androgen deficiency in men means the body has lower than normal amounts of male hormones, including testosterone, according to background information in the article. Although prescriptions for testosterone therapy for aging men have increased in recent years, treatment patterns for androgen deficiency are not clearly understood in community-dwelling U.S. males.
Susan A. Hall, Ph.D., of New England Research Institutes, Watertown, Mass., and colleagues examined data collected from 1,486 Boston-area men (average age 46.4) from April 2002 to June 2005 to estimate the number of men receiving treatment for androgen deficiency, to explain how treated and untreated men varied in seeking care and to understand potential barriers to health care. Specific symptoms of androgen deficiency include low libido, erectile dysfunction and osteoporosis and less-specific symptoms include sleep disturbance, depressed mood and tiredness.
Testosterone predicts profits on trading floors
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Financial traders make more money when their testosterone levels are high, perhaps because the male hormone makes them more confident and focused, British researchers reported on Monday.
Their study of male traders in the City of London financial district showed they made bigger profits on days when their testosterone levels were already high.
Testosterone may help focus the mind but constantly high testosterone levels are likely to make traders foolhardy, the researchers at the University of Cambridge cautioned.
New Study Finds Anticipating a Laugh Reduces Stress Hormones
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In 2006 researchers investigating the interaction between the brain, behavior, and the immune system found that simply anticipating a mirthful laughter experience boosted health-protecting hormones. Now, two years later, the same researchers have found that the anticipation of a positive humorous laughter experience also reduces potentially detrimental stress hormones. According to Dr. Lee Berk, the study team’s lead researcher of Loma Linda University, Loma Linda, CA, “Our findings lead us to believe that by seeking out positive experiences that make us laugh we can do a lot with our physiology to stay well.”
In their earlier work the researchers found that the anticipation of “mirthful laughter” had surprising and significant effects. Two hormones – beta-endorphins (the family of chemicals that alleviates depression) and human growth hormone (HGH; which helps with immunity) – increased by 27 and 87 percent respectively when volunteers anticipated watching a humorous video. There was no such increase among the control group who did not anticipate watching the humor film.
Mother-daughter conflict, low serotonin level may be deadly combination
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A combination of negative mother-daughter relationships and low blood levels of serotonin, an important brain chemical for mood stability, may be lethal for adolescent girls, leaving them vulnerable to engage in self-harming behaviors such as cutting themselves.
New University of Washington research indicates that these two factors in combination account for 64 percent of the difference among adolescents, primarily girls, who engage in self-harming behaviors and those who do not.
“Girls who engage in self harm are at high risk for attempting suicide, and some of them are dying,” said Theodore Beauchaine, a UW associate professor of psychology and co-author of a new study. “There is no better predictor of suicide than previous suicide attempts.”
Intranasal Insulin May Lower Food Intake in Men, Improve Memory Function in Women
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Insulin administered intranasally, acutely decreases food intake in men but not women and in contrast, the compound improves memory function in women but not men according to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM).
“Our findings indicate that gender is a critical factor in brain insulin signaling that affects both food intake and cognitive functions,” said Dr. Christian Benedict of the University of Lubeck in Germany. “They further suggest that intranasal insulin may be helpful in the treatment of cognitive and metabolic disorders like Alzheimer’s disease and obesity that are assumed to derive at least in part from malfunctions of central nervous insulin signaling.”
Previous studies have shown that insulin plays a pivotal role in the regulation of central nervous functions such as energy metabolism and memory processing. This study set out to assess the effects of a single dose of intranasal insulin on these functions and to determine any gender differences.
Female-to-Male Transsexuals Have Higher Androgen Levels, Not PCOS
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Contrary to previous studies, female-to-male transsexuals do not have a higher prevalence of polycystic ovary syndrome (PCOS), though they do have significantly higher androgen levels, according to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM).
PCOS is an endocrine disorder with a host of symptoms related to small painful cysts on the ovaries. It is marked by the overproduction of male hormones in females. Until now, it has been postulated that the prevalence of PCOS in female-to-male transsexuals is higher than normal.
“Several studies have reported a higher prevalence of PCOS in female-to-male transsexuals but the numbers of patients were small and ultrasound was not used for diagnosis,” said Dr. Andreas Mueller of Erlangen University Hospital in Erlangen, Germany. “This is the first prospective endocrine evaluation of female-to-male transsexuals using up-to-date state-of-the-art criteria incorporating transvaginal ultrasonography for diagnosing PCOS or hyperandrogenemia.”
Combined HRT Increases Risk of Lobular Breast Cancer Fourfold After Just Three Years of Use
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Postmenopausal women who take combined estrogen/progestin hormone-replacement therapy for three years or more face a fourfold increased risk of developing various forms of lobular breast cancer, according to new findings by researchers at Fred Hutchinson Cancer Research Center.
“Previous research indicated that five or more years of combined hormone-therapy use was necessary to increase overall breast-cancer risk,” said Christopher I. Li, M.D., Ph.D., the lead author of the report, published in the January issue of Cancer Epidemiology, Biomarkers and Prevention. “Our study, the first specifically designed to evaluate the relationship between combined HRT and lobular breast cancers, suggests that a significantly shorter length of exposure to such hormones may confer an increased risk.”
The study, which confirms previous reports of the association between combined hormone-therapy use and increased risk of lobular breast cancers, is the largest study of combined HRT and lobular cancer risk in the United States. It is also the first such study to take into account the recency and duration of hormone use and the first to include a centralized pathological review of tumor specimens to confirm their histological type: ductal, lobular or mixed ductal-lobular.
Testosterone patch has benefits in aging men: study
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Treatment with testosterone can help curb the gain in abdominal fat as well as the loss of skeletal muscle seen in non-obese aging men, according to a new study.
“Though use of testosterone therapy as a means of defying the aging process is gaining popularity, data from scientific trials have been very limited in this area,” study chief Dr. Carolyn Allan, from Prince Henry’s Institute in Victoria, Australia, said in a statement.
Natural human hormone as the next antidepressant?
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Novel treatment strategies for major depression with broader treatment success or a more rapid onset of action would have immense impact on public health, a new study published in the December 1st issue of Biological Psychiatry explains. This new study reports findings that support the evaluation of a potential new antidepressant agent.
According to the lead author on this study, Kamilla Miskowiak, MSc: “Although depression is often related to problems in the chemistry of the brain, recent evidence also suggests that there may be structural problems as well with nerve cells not being regenerated as fast as normal or suffering from toxic effects of stress and stress hormones.”
Low testosterone in men linked to earlier death
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Older men with low levels of the hormone testosterone may die sooner than other men their age with normal testosterone levels, a study suggests.
Researchers found that among 794 generally healthy older men, those with the lowest testosterone levels were 40 percent more likely to die within the 1985-2004 study period.
Hunger hormone fights aging in the thymus
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The deterioration in immune function that occurs as an individual ages is thought to occur because the thymus involutes with age, causing a dramatic decrease in T cell output. New data generated by Dennis Taub and colleagues from the National Institutes of Health, Baltimore, suggest that in mice, thymic involution is caused by a decrease upon aging in thymic expression of both a hormone that is better known as a stimulator of food intake (ghrelin) and its receptor.
These results led them to caution that care should be taken when considering blocking ghrelin as a potential approach for treating individuals who are obese and to suggest that harnessing this pathway might provide a new approach to boost immune function in individuals who are elderly or immunocompromised.
New Studies Indicate Age is Important in Hormone Therapy Use
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Five years ago this summer the National Institutes of Health’s stopped early a major portion of the Women’s Health Initiative (WHI), a large and ambitious study to address the most common causes of death, disability and impaired quality of life in postmenopausal women.
One part of the WHI sought to determine whether hormone therapy has a positive or negative impact on cardiovascular disease, cancer, and osteoporosis. The estrogen-plus-progestin hormone therapy trial for women with their uteruses intact was stopped in July 2002 after investigators found that the associated health risks of the combination hormone therapy outweighed the benefits.
High Blood Levels of Urate Linked to Lower Risk of Parkinson’s Disease
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In a new, large-scale, prospective study exploring the link between levels of urate in the blood and risk of Parkinson’s disease, researchers from the Harvard School of Public Health (HSPH) have found that high levels of urate are strongly associated with a reduced risk of the disease. The findings were published online on June 20, 2007 in The American Journal of Epidemiology and will appear in an upcoming print issue of the journal.
Urate is a normal component of blood, and although high levels can lead to gout, urate might also have beneficial effects because it is a potent antioxidant. Parkinson’s disease is a chronic, progressive nerve disorder associated with destruction of brain cells producing dopamine, a neurotransmitter essential to the normal functioning of the central nervous system.
Women undergoing HRT face increased risk of getting cancer
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It was once described as the last frontier in the emancipation of women, a pill that would ease the transition through the menopause and allow those who took it to slip into a contented middle age. Now the world’s largest study of hormone replacement therapy (HRT) has shown that it may have caused 1,000 deaths from ovarian cancer between 1991 and 2005.
The new finding strengthens the evidence that HRT poses a serious danger to women. Previous results from the same study have shown that the risk of breast cancer and endometrial cancer (of the lining of the womb) is also increased by the treatment.
