Neurology
New Clue Why MS Affects African Americans Differently than Caucasians
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Differences in immune systems have been found in African Americans with multiple sclerosis (MS) compared to Caucasians, possibly offering a clue why African Americans experience more disability with MS than Caucasians, according to a study published in the July 3, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.
For the study, researchers compared levels of antibodies in the cerebrospinal fluid of 66 African Americans to 132 Caucasians with MS.
Promising results from first gene therapy clinical trial for Parkinson’s disease reported
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In what could be a breakthrough in the treatment of neurological disease, a team led by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center has completed the first-ever phase 1 clinical trial using gene therapy to battle Parkinson’s disease.
The study of 11 men and one woman with the progressive neurodegenerative illness found that the procedure—in which surgeons inject a harmless gene-bearing virus into the brain—was both safe and resulted in improved motor function for Parkinson’s patients over the course of one year. The findings are published in the June 23 issue of The Lancet.
High Blood Levels of Urate Linked to Lower Risk of Parkinson’s Disease
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In a new, large-scale, prospective study exploring the link between levels of urate in the blood and risk of Parkinson’s disease, researchers from the Harvard School of Public Health (HSPH) have found that high levels of urate are strongly associated with a reduced risk of the disease. The findings were published online on June 20, 2007 in The American Journal of Epidemiology and will appear in an upcoming print issue of the journal.
Urate is a normal component of blood, and although high levels can lead to gout, urate might also have beneficial effects because it is a potent antioxidant. Parkinson’s disease is a chronic, progressive nerve disorder associated with destruction of brain cells producing dopamine, a neurotransmitter essential to the normal functioning of the central nervous system.
CPAP improves sleep in patients with Alzheimer’s disease, sleep-related breathing disorder
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Patients with both Alzheimer disease and a sleep-related breathing disorder (SRBD) experience disrupted sleep, resulting in increased nocturnal awakenings and a decreased percentage of REM sleep. However, in another example of the effectiveness of continuous positive airway pressure (CPAP), CPAP has been found to reduce the amount of time spent awake during the night, increase the time spent in deeper levels of sleep, and improve oxygenation, according to a research abstract that will be presented Monday at SLEEP 2007, the 21st Annual Meeting of the Associated Professional Sleep Societies (APSS).
The study, conducted by Jana R. Cooke, MD, of the University of California at San Diego, was focused on 48 adults, with an average age of 77.8 years, with Alzheimer disease and an SRBD. It was discovered that treating the sleep-related breathing disorder with CPAP resulted in these patients spending less time awake during the night as well as sleeping deeper.
Advances in Treatment of Epilepsy and Related Seizure Disorders Help Improve Quality of Life
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Epilepsy and seizures affect 2.5 million Americans, 181,000 new cases of epilepsy are diagnosed every year, and the disorder incurs an estimated $12.5 billion in annual direct and indirect costs. About 450,000 children ages 15 and younger develop epilepsy each year, and of these, 315,000 are school-aged children. Children and adolescents are more likely to have epilepsy of unknown or genetic origin. The rate of new cases in children is highest before age 2, gradually declines until about age 10, and then stabilizes.
“Brain injury or infection can cause epilepsy at any age; however, the cause of epilepsy is unknown for about half of all individuals with the disorder,” said Howard Weiner, MD, a pediatric epilepsy neurosurgeon at NYU Comprehensive Epilepsy Center, and an American Association of Neurological Surgeons (AANS) spokesperson. Children may be born with a defect in the structure of their brain, or they may suffer a head injury or infection that causes their epilepsy. Severe head injury is the most common known cause in young adults. In middle age, strokes, tumors, and injuries are more frequent cause. In people age 65 and older, stroke is the most common known cause, followed by degenerative conditions such as Alzheimer’s disease. Seizures may not begin immediately after a person incurs a brain injury – seizures may occur many months later.
Alzheimer’s: The History of Forgetting
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When I first started writing about aging issues in 1991, I had to define Alzheimer’s disease with each reference. “Alzheimer’s leads to progressive memory loss,” I would write.
People liked to associate the disease with age. We’re seeing more of it, people would say, because everyone lives longer.
Statin treatment improves spatial memory in mouse models of Alzheimer’s
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Treatment with Simvastatin, one of the statin drugs widely used for lowering cholesterol in humans, significantly improved spatial memory - how to navigate a water maze - in mice genetically bred to have an Alzheimer’s like disease. Although statin improved memory in both males and females, the results were more pronounced in males.
Dr. H. A. Morcos, chair of Pharmacology at the American University of Antigua, and colleagues at Florida A & M University presented the study April 30 at Experimental Biology 2007 in Washington, DC. His presentation is part of the scientific program of the American Society for Pharmacology and Experimental Therapeutics.
Migraine linked to heart attacks in men
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Men with migraine headaches are more likely than non-migraineurs to experience a heart attack, according to data from the Physicians’ Health Study.
The Physicians’ Health Study is a large study that enrolled men ages 40 to 84 years between 1981 and 1984. The subjects, who had no history of heart disease, cancer or other major illnesses at enrollment, complete questionnaires annually regarding health issues.
Study Shows Hope for Early Diagnosis of Alzheimer’s
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Research by faculty and staff at Rowan University, Glassboro, N.J.; the University of Pennsylvania School of Medicine; and Drexel University may lead to better diagnosis of early-stage Alzheimer’s disease.
In a $1.1-million National Institutes of Health’s National Institute on Aging study that team members conducted during the last three years, they determined early Alzheimer’s could be diagnosed with a high rate of accuracy evaluating electroencephalogram (EEG) signals. The study may lead to an earlier diagnosis, and therefore earlier treatment and improved quality of life, for people at the earliest stages of the disease.
Researchers show how obesity causes breakdown in system which regulates appetite and weight
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New research led by scientists at the Oregon National Primate Research Center demonstrates how obesity causes the breakdown of a brain system that regulates appetite. The research provides a clear picture of some factors involved in obesity. More than 60 percent of American adults are overweight and more than 30 percent are obese The study results may have also identified possible targets for new drug therapies aimed at assisting individuals in weight loss. The research is published in the March issue of Cell Metabolism.
The research provides new understanding of leptin resistance. Leptin is a hormone secreted by fat cells. It can suppress food intake by affecting brain cells that control appetite. However, high levels of leptin which can be found in severely overweight individuals, can lead to leptin resistance. Leptin resistance means that the body no longer responds to the hormone’s weight suppressing effects.
Smoking changes brain the same way as drugs do
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Smoking causes long-lasting changes in the brain similar to changes seen in animals when they are given cocaine, heroin and other addictive drugs, U.S. researchers said on Tuesday.
A study of the brain tissue of smokers and nonsmokers who died showed that smokers had these changes, even if they had quit years before, the team at the National Institute on Drug Abuse (NIDA) reported.
Pregnancy hormone increases nerve cells’ insulation, restores damage
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A hormone produced during pregnancy spontaneously increases myelin, which enhances signaling within the nervous system, and helps repair damage in the brain and spinal cord, according to new animal research.
The findings, published in the February 21 Journal of Neuroscience, indicate that the hormone prolactin promotes an increase in myelin production and may have a use in treating multiple sclerosis (MS).
Learning slows physical progression of Alzheimer’s disease
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Learning appears to slow the development of two brain lesions that are the hallmarks of Alzheimer’s disease, scientists at UC Irvine have discovered. The finding suggests that the elderly, by keeping their minds active, can help delay the onset of this degenerative disease.
This study with genetically modified mice is the first to show that short but repeated learning sessions can slow a process known for causing the protein beta amyloid to clump in the brain and form plaques, which disrupt communication between cells and lead to symptoms of Alzheimer’s disease. Learning also was found to slow the buildup of hyperphosphorylated-tau, a protein in the brain that can lead to the development of tangles, the other signature lesion of the disease. Scientists say these findings have large implications for the understanding and treatment of Alzheimer’s disease, as it is already known that highly educated individuals are less likely to develop the disease than people with less education.
Cholesterol decline may signal early dementia
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A decline in total cholesterol levels may precede the diagnosis of dementia by at least 15 years, according to a study reported in the Archives of Neurology.
“Studies like this are extremely valuable because they can provide a ‘window’ on to processes going on early in dementia, allowing researchers to look back in time at people’s health and other characteristics and compare these between people who develop dementia and those who do not,” Dr. Robert Stewart from King’s College London, told Reuters Health.
Genetic variation may reduce Alzheimer’s risk
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Adults with a genetic variation enabling them to express higher levels of fetal hemoglobin may have a reduced risk of Alzheimer’s disease, researchers say.
A study of 209 families with at least two siblings with Alzheimer’s and one unaffected sibling showed that those with this genetic variation are less likely to have the disease, researchers say in Neurobiology of Aging. An estimated 25 percent of the population has the XmnI polymorphism.
