Bladder cancer
Certain meat components may increase bladder cancer risk
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A new study suggests that consuming specific compounds in meat related to processing methods may be associated with an increased risk of developing bladder cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may be relevant for understanding the role of dietary exposures in cancer risk.
Eating red and processed meats has been linked to an increased risk of developing several different types of cancer. Animal studies have identified a number of compounds in meat that might account for this association. These include heterocyclic amines, polycyclic aromatic hydrocarbons, and N-nitroso compounds. Nitrate and nitrite are added to processed meats and are known precursors to N-nitroso compounds.
Amanda J. Cross, PhD, of the National Cancer Institute in Rockville and colleagues conducted one of the first prospective studies – the NIH-AARP Diet and Health Study—to assess the relationship between intake of these meat-related compounds and the risk of developing bladder cancer. They used information gathered through questionnaires to assess the types of meat consumed as well as how meat was prepared and cooked to estimate the intake of these meat-related compounds.
“Don’t eat me” sign helps bladder tumors escape
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Researchers said on Monday they had found primitive bladder cancer cells that cloak themselves with a “don’t eat me” signal that scares off immune system cells, allowing them to mature into tumors later on.
But they found a way to unmask this disguise and said their findings may lead to new approaches for treating cancers of several different types.
The immediate hope is to find a way of telling apart patients who have dangerous bladder cancer from those who have more benign forms. Bladder cancer is mostly slow-growing and easily treated, but 15 percent of cases become invasive and deadly.
Pregnancy may help protect against bladder cancer
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Pregnancy seems to confer some protection against bladder cancer in mice, scientists have found.
Female mice that had never become pregnant had approximately 15 times as much cancer in their bladders as their counterparts that had become pregnant, according to new findings by investigators at the University of Rochester Medical Center. Their work appears online as a rapid communication in the journal Urology.
The researchers led by Jay Reeder, Ph.D., are focusing on a fact that has puzzled doctors and scientists for decades: Why does bladder cancer, the fifth most common malignancy in the nation, affect about three times as many men as women? Scientists long blamed men’s historically higher rates of smoking and greater exposure to dangers in the workplace, but the gap has persisted even as women swelled the workforce and took up smoking in greater numbers.
