Alprostadil (Local)

Brand Names : Caverject, Edex, Muse, Prostin VR Pediatric, Prostin VR, PGE 1, prostaglandin E 1

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For alprostadil, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to alprostadil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Older adults - This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems - The presence of other medical problems may affect the use of alprostadil. Make sure you tell your doctor if you have any other medical problems, especially:

• Abnormal penis, including curved penis and birth defects of the penis - Chance of problems occurring may be increased

• Bleeding problems - Chance of bleeding at the place of injection may be increased

• Infection of penis or
• Red or itchy (inflamed) penis - Conditions may worsen with the use of alprostadil suppositories. Also, local skin problems and minor bleeding from inserting the suppository may occur

• Conditions causing thickened blood or slower blood flow, including leukemia; multiple myeloma (tumors of the bone marrow); polycythemia, sickle cell disease, or thrombocythemia (blood problems) or

• Priapism (history of) - Patients with these conditions have an increased risk of priapism (erection lasting longer than 6 hours) while using alprostadil