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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Barbiturates, Aspirin, and Codeine : Before Using

Barbiturates, Aspirin, and Codeine (Systemic)

Barbiturates, Aspirin, and Codeine | Before Using | Proper Use | Precautions | Side Effects

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For barbiturate, aspirin, and codeine combinations, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to aspirin or other salicylates including methyl salicylate (oil of wintergreen); butalbital, phenobarbital, or other barbiturates; caffeine; codeine; or any of the following medicines:

  • Diclofenac (e.g., Voltaren)
  • Diflunisal (e.g., Dolobid)
  • Etodolac (e.g., Lodine)
  • Fenoprofen (e.g., Nalfon)
  • Floctafenine (e.g., Idarac)
  • Flurbiprofen, oral (e.g., Ansaid)
  • Ibuprofen (e.g., Motrin)
  • Indomethacin (e.g., Indocin)
  • Ketoprofen (e.g., Orudis)
  • Ketorolac (e.g., Toradol)
  • Meclofenamate (e.g., Meclomen)
  • Mefenamic acid (e.g., Ponstel)
  • Nabumetone (e.g., Relafen)
  • Naproxen (e.g., Naprosyn)
  • Oxaprozin (e.g., Daypro)
  • Oxyphenbutazone (e.g., Tandearil)
  • Phenylbutazone (e.g., Butazolidin)
  • Piroxicam (e.g., Feldene)
  • Sulindac (e.g., Clinoril)
  • Suprofen (e.g., Suprol)
  • Tenoxicam (e.g., Mobiflex)
  • Tiaprofenic acid (e.g., Surgam)
  • Tolmetin (e.g., Tolectin)
  • Zomepirac (e.g., Zomax)

Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy -

  • For butalbital or phenobarbital : Barbiturates have been shown to increase the chance of birth defects in humans. Also, one study in humans has suggested that barbiturates taken during pregnancy may increase the chance of brain tumors in the baby. Barbiturates may cause breathing problems in the newborn baby if taken just before or during delivery.
  • For aspirin : Although studies in humans have not shown that aspirin causes birth defects, aspirin has caused birth defects in animal studies.
    Do not take aspirin during the last 3 months of pregnancy unless it has been ordered by your doctor . Some reports have suggested that use of aspirin late in pregnancy may cause a decrease in the newborn's weight and possible death of the fetus or newborn baby. However, the mothers in these reports had been taking much larger amounts of aspirin than are usually recommended. Studies of mothers taking aspirin in the doses that are usually recommended did not show these unwanted effects.
    There is a chance that regular use of aspirin late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or in the newborn baby. Also, use of aspirin during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery or in the newborn baby. In addition, too much use of aspirin during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery.
  • For codeine : Although studies on birth defects with codeine have not been done in pregnant women, it has not been reported to cause birth defects. However, it may cause breathing problems in the newborn baby if taken just before or during delivery. Codeine did not cause birth defects in animal studies, but it caused slower development of bones and other harmful effects in the fetus.
  • For caffeine : Studies in humans have not shown that caffeine causes birth defects. However, use of large amounts of caffeine during pregnancy may cause problems with the heart rhythm and the growth of the fetus. Also, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to those in 12 to 24 cups of coffee a day).

Breast-feeding - Although this combination medicine has not been reported to cause problems, the chance always exists, especially if the medicine is taken for a long time or in large amounts.

  • For butalbital or phenobarbital : Barbiturates pass into the breast milk and may cause drowsiness, unusually slow heartbeat, shortness of breath, or troubled breathing in nursing babies.
  • For aspirin : Aspirin passes into the breast milk. However, taking aspirin in the amount present in these combination medicines has not been reported to cause problems in nursing babies.
  • For codeine : Codeine passes into the breast milk in small amounts. However, it has not been reported to cause problems in nursing babies.
  • For caffeine : The caffeine in the butalbital, aspirin, and codeine combination medicine passes into the breast milk in small amounts. Taking caffeine in the amounts present in this combination medicine has not been reported to cause problems in nursing babies. However, studies have shown that nursing babies may appear jittery when their mothers drink large amounts of caffeine-containing beverages. Therefore, breast-feeding mothers who use caffeine-containing medicines should probably limit the amount of caffeine they take in from other medicines or from beverages.

Children -

  • For butalbital or phenobarbital : Although barbiturates often cause drowsiness, some children become excited after taking them.
  • For aspirin: Do not give a medicine containing aspirin to a child with fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor . This is very important because aspirin may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.
  • For caffeine : There is no specific information comparing use of caffeine in children up to 12 years of age with use in other age groups. However, caffeine is not expected to cause different side effects or problems in children than it does in adults.

Adolescents - Teenagers with fever or other symptoms of a virus infection, especially flu or chickenpox, should check with a doctor before taking this medicine . The aspirin in this combination medicine may cause a serious illness called Reye's syndrome in teenagers with fever caused by a virus infection, especially flu or chickenpox.

Older adults -

  • For butalbital or phenobarbital : Confusion, depression, or excitement may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of barbiturates.
  • For aspirin : Elderly patients are more sensitive than younger adults to the effects of aspirin. This may increase the chance of side effects during treatment.
  • For codeine : Breathing problems may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of codeine.
  • For caffeine : Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of caffeine in the elderly with use in other age groups.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this combination medicine, it is especially important that your health care professional know if you are taking any of the following:

  • Antacids, large amounts taken regularly, especially calcium- and/or magnesium-containing antacids or sodium bicarbonate (baking soda), or
  • Urinary alkalizers (medicine that makes the urine less acid, such as acetazolamide [e.g., Diamox], dichlorphenamide [e.g., Daranide], methazolamide [e.g., Neptazane], potassium or sodium citrate and/or citric acid) - These medicines may cause aspirin to be removed from the body faster than usual, which may shorten the length of time that aspirin is effective; acetazolamide, dichlorphenamide, and methazolamide may also increase the chance of side effects when taken together with aspirin
  • Anticoagulants (blood thinners) or
  • Heparin - Use of these medicines together with aspirin may increase the chance of bleeding; also, barbiturates, especially phenobarbital, may decrease the effects of anticoagulants
  • Antidepressants, tricyclic (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) or
  • Central nervous system (CNS) depressants (medicines that often cause drowsiness) - These medicines may add to the effects of barbiturates and codeine and increase the chance of drowsiness or other side effects
  • Carbamazepine or
  • Contraceptives, oral (birth control pills) containing estrogens or
  • Corticosteroids (cortisone-like medicines) or
  • Corticotropin (ACTH) - Barbiturates, especially phenobarbital, may make these medicines less effective
  • Divalproex (e.g., Depakote) or
  • Methotrexate (e.g., Mexate) or
  • Valproic acid (e.g., Depakene) or
  • Vancomycin (e.g., Vancocin) - The chance of serious side effects may be increased
  • Naltrexone (e.g., Trexan) - Naltrexone blocks the pain-relieving effect of codeine
  • Probenecid (e.g., Benemid) or
  • Sulfinpyrazone (e.g., Anturane) - Aspirin can keep these medicines from working properly for treating gout

Other medical problems - The presence of other medical problems may affect the use of butalbital, aspirin, and codeine combination. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Drug abuse or dependence (or history of) - Dependence on barbiturates and/or codeine may develop
  • Asthma, especially if occurring together with other allergies and nasal polyps (history of), or
  • Brain disease or head injury or
  • Colitis or
  • Convulsions (seizures) (history of) or
  • Emphysema or other chronic lung disease or
  • Enlarged prostate or problems with urination or
  • Gallbladder disease or gallstones or
  • Hyperactivity (in children) or
  • Kidney disease or
  • Liver disease - The chance of serious side effects may be increased
  • Diabetes mellitus (sugar diabetes) or
  • Mental depression or
  • Overactive thyroid or
  • Porphyria (or history of) - Barbiturates can make these conditions worse
  • Gout - Aspirin can make this condition worse and can also lessen the effects of some medicines used to treat gout
  • Heart disease (severe) - The caffeine in the butalbital, aspirin, and codeine combination can make some kinds of heart disease worse
  • Hemophilia or other bleeding problems or
  • Vitamin K deficiency - Aspirin increases the chance of serious bleeding
  • Stomach ulcer, especially with a history of bleeding, or other stomach problems - Aspirin can make your condition worse

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Barbiturates, Aspirin, and Codeine: Description and Brand Names

 

Barbiturates, Aspirin, and Codeine: Proper Use



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