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$alt_texts= array ('Benign prostatic hyperplasia, or BPH for short, is the enlargement of the prostate gland. It is caused by excess growth of cells in the prostate. This condition is not the same as prostate cancer','Alternate Names : Dysmenorrhea. Menstrual cramps are the pain and cramping some women experience during their monthly periods. The term dysmenorrhea usually refers to pain and cramps severe enough to prevent normal activity','An ectopic pregnancy occurs when a fertilized egg implants outside of the uterus. The most common site is within a fallopian tube. More rarely an embryo may implant within an ovary, in the cervix, or on the abdominal wall','Pregnancy is the period from conception to birth. A pregnancy may be complicated by health problems or lifestyle issues known as risk factors. These risk factors can affect the mother or fetus, or both','Topiramate (toe-PYRE-a-mate) is used to help control some types of seizures in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to help control seizures for as long as you continue to take it.','Irritable bowel syndrome, or IBS, is a condition characterized by abdominal cramping, bloating, gas, and other changes in the bowels','Depression is a medical condition that leads to intense feelings of sadness or despair. These feelings don\'t go away on their own. They are not necessarily related to a particular life event','Tacrolimus ( ta-KROE-li-mus) ointment is used for moderate to severe atopic dermatitis. This is a skin condition where there is itching, redness and inflammation, much like an allergic reaction','Type 2 diabetes mellitus, more often known as type 2 diabetes, is the most common type of diabetes','Personality disorders are chronic mental disorders','Presbyopia is an eye condition in which the lens loses the ability to focus over time');
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Barbiturates, Aspirin, and Codeine (Systemic)
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Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For barbiturate, aspirin,
and codeine combinations, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to aspirin or other salicylates including methyl salicylate
(oil of wintergreen); butalbital, phenobarbital, or other barbiturates; caffeine;
codeine; or any of the following medicines:
-
Diclofenac (e.g., Voltaren)
-
Diflunisal (e.g., Dolobid)
-
Etodolac (e.g., Lodine)
-
Fenoprofen (e.g., Nalfon)
-
Floctafenine (e.g., Idarac)
-
Flurbiprofen, oral (e.g., Ansaid)
-
Ibuprofen (e.g., Motrin)
-
Indomethacin (e.g., Indocin)
-
Ketoprofen (e.g., Orudis)
-
Ketorolac (e.g., Toradol)
-
Meclofenamate (e.g., Meclomen)
-
Mefenamic acid (e.g., Ponstel)
-
Nabumetone (e.g., Relafen)
-
Naproxen (e.g., Naprosyn)
-
Oxaprozin (e.g., Daypro)
-
Oxyphenbutazone (e.g., Tandearil)
-
Phenylbutazone (e.g., Butazolidin)
-
Piroxicam (e.g., Feldene)
-
Sulindac (e.g., Clinoril)
-
Suprofen (e.g., Suprol)
-
Tenoxicam (e.g., Mobiflex)
-
Tiaprofenic acid (e.g., Surgam)
-
Tolmetin (e.g., Tolectin)
-
Zomepirac (e.g., Zomax)
Also tell your health care professional if you are allergic to any other
substances, such as foods, preservatives, or dyes.
Pregnancy -
-
For butalbital or phenobarbital
: Barbiturates
have been shown to increase the chance of birth defects in humans. Also, one
study in humans has suggested that barbiturates taken during pregnancy may
increase the chance of brain tumors in the baby. Barbiturates may cause breathing
problems in the newborn baby if taken just before or during delivery.
-
For aspirin
: Although studies in humans
have not shown that aspirin causes birth defects, aspirin has caused birth
defects in animal studies.
Do not take aspirin during the last 3 months of pregnancy
unless it has been ordered by your doctor
. Some reports have suggested
that use of aspirin late in pregnancy may cause a decrease in the newborn's
weight and possible death of the fetus or newborn baby. However, the mothers
in these reports had been taking much larger amounts of aspirin than are usually
recommended. Studies of mothers taking aspirin in the doses that are usually
recommended did not show these unwanted effects. There is a chance that regular use of aspirin late in pregnancy may cause
unwanted effects on the heart or blood flow in the fetus or in the newborn
baby. Also, use of aspirin during the last 2 weeks of pregnancy may cause
bleeding problems in the fetus before or during delivery or in the newborn
baby. In addition, too much use of aspirin during the last 3 months of pregnancy
may increase the length of pregnancy, prolong labor, cause other problems
during delivery, or cause severe bleeding in the mother before, during, or
after delivery.
-
For codeine
: Although studies on birth
defects with codeine have not been done in pregnant women, it has not been
reported to cause birth defects. However, it may cause breathing problems
in the newborn baby if taken just before or during delivery. Codeine did not
cause birth defects in animal studies, but it caused slower development of
bones and other harmful effects in the fetus.
-
For caffeine
: Studies in humans have not
shown that caffeine causes birth defects. However, use of large amounts of
caffeine during pregnancy may cause problems with the heart rhythm and the
growth of the fetus. Also, studies in animals have shown that caffeine causes
birth defects when given in very large doses (amounts equal to those in 12
to 24 cups of coffee a day).
Breast-feeding - Although this combination medicine has not been
reported to cause problems, the chance always exists, especially if the medicine
is taken for a long time or in large amounts.
-
For butalbital or phenobarbital
: Barbiturates
pass into the breast milk and may cause drowsiness, unusually slow heartbeat,
shortness of breath, or troubled breathing in nursing babies.
-
For aspirin
: Aspirin passes into the breast
milk. However, taking aspirin in the amount present in these combination medicines
has not been reported to cause problems in nursing babies.
-
For codeine
: Codeine passes into the breast
milk in small amounts. However, it has not been reported to cause problems
in nursing babies.
-
For caffeine
: The caffeine in the butalbital,
aspirin, and codeine combination medicine passes into the breast milk in small
amounts. Taking caffeine in the amounts present in this combination medicine
has not been reported to cause problems in nursing babies. However, studies
have shown that nursing babies may appear jittery when their mothers drink
large amounts of caffeine-containing beverages. Therefore, breast-feeding
mothers who use caffeine-containing medicines should probably limit the amount
of caffeine they take in from other medicines or from beverages.
Children -
-
For butalbital or phenobarbital
: Although
barbiturates often cause drowsiness, some children become excited after taking
them.
-
For aspirin: Do not give a medicine containing
aspirin to a child with fever or other symptoms of a virus infection, especially
flu or chickenpox, without first discussing its use with your child's doctor
. This is very important because aspirin may cause a serious illness
called Reye's syndrome in children with fever caused by a virus infection,
especially flu or chickenpox. Children who do not have a virus infection may
also be more sensitive to the effects of aspirin, especially if they have
a fever or have lost large amounts of body fluid because of vomiting, diarrhea,
or sweating. This may increase the chance of side effects during treatment.
-
For caffeine
: There is no specific information
comparing use of caffeine in children up to 12 years of age with use in other
age groups. However, caffeine is not expected to cause different side effects
or problems in children than it does in adults.
Adolescents - Teenagers with fever or other
symptoms of a virus infection, especially flu or chickenpox, should check
with a doctor before taking this medicine
. The aspirin in this combination
medicine may cause a serious illness called Reye's syndrome in teenagers with
fever caused by a virus infection, especially flu or chickenpox.
Older adults -
-
For butalbital or phenobarbital
: Confusion,
depression, or excitement may be especially likely to occur in elderly patients,
who are usually more sensitive than younger adults to the effects of barbiturates.
-
For aspirin
: Elderly patients are more
sensitive than younger adults to the effects of aspirin. This may increase
the chance of side effects during treatment.
-
For codeine
: Breathing problems may be
especially likely to occur in elderly patients, who are usually more sensitive
than younger adults to the effects of codeine.
-
For caffeine
: Many medicines have not
been studied specifically in older people. Therefore, it may not be known
whether they work exactly the same way they do in younger adults or if they
cause different side effects or problems in older people. There is no specific
information comparing use of caffeine in the elderly with use in other age
groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
this combination medicine, it is especially important that your health care
professional know if you are taking any of the following:
-
Antacids, large amounts taken regularly, especially calcium- and/or
magnesium-containing antacids or sodium bicarbonate (baking soda), or
-
Urinary alkalizers (medicine that makes the urine less acid, such
as acetazolamide [e.g., Diamox], dichlorphenamide [e.g., Daranide], methazolamide
[e.g., Neptazane], potassium or sodium citrate and/or citric acid) - These
medicines may cause aspirin to be removed from the body faster than usual,
which may shorten the length of time that aspirin is effective; acetazolamide,
dichlorphenamide, and methazolamide may also increase the chance of side effects
when taken together with aspirin
-
Anticoagulants (blood thinners) or
-
Heparin - Use of these medicines together with aspirin may increase
the chance of bleeding; also, barbiturates, especially phenobarbital, may
decrease the effects of anticoagulants
-
Antidepressants, tricyclic (amitriptyline [e.g., Elavil], amoxapine
[e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane],
doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g.,
Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])
or
-
Central nervous system (CNS) depressants (medicines that often cause
drowsiness) - These medicines may add to the effects of barbiturates and
codeine and increase the chance of drowsiness or other side effects
-
Carbamazepine or
-
Contraceptives, oral (birth control pills) containing estrogens or
-
Corticosteroids (cortisone-like medicines) or
-
Corticotropin (ACTH) - Barbiturates, especially phenobarbital,
may make these medicines less effective
-
Divalproex (e.g., Depakote) or
-
Methotrexate (e.g., Mexate) or
-
Valproic acid (e.g., Depakene) or
-
Vancomycin (e.g., Vancocin) - The chance of serious side effects
may be increased
-
Naltrexone (e.g., Trexan) - Naltrexone blocks the pain-relieving
effect of codeine
-
Probenecid (e.g., Benemid) or
-
Sulfinpyrazone (e.g., Anturane) - Aspirin can keep these medicines
from working properly for treating gout
Other medical problems - The presence of other medical
problems may affect the use of butalbital, aspirin, and codeine combination.
Make sure you tell your doctor if you have any other medical problems, especially:
-
Alcohol abuse (or history of) or
-
Drug abuse or dependence (or history of) - Dependence on barbiturates
and/or codeine may develop
-
Asthma, especially if occurring together with other allergies and
nasal polyps (history of), or
-
Brain disease or head injury or
-
Colitis or
-
Convulsions (seizures) (history of) or
-
Emphysema or other chronic lung disease or
-
Enlarged prostate or problems with urination or
-
Gallbladder disease or gallstones or
-
Hyperactivity (in children) or
-
Kidney disease or
-
Liver disease - The chance of serious side effects may be increased
-
Diabetes mellitus (sugar diabetes) or
-
Mental depression or
-
Overactive thyroid or
-
Porphyria (or history of) - Barbiturates can make these conditions
worse
-
Gout - Aspirin can make this condition worse and can also lessen
the effects of some medicines used to treat gout
-
Heart disease (severe) - The caffeine in the butalbital, aspirin,
and codeine combination can make some kinds of heart disease worse
-
Hemophilia or other bleeding problems or
-
Vitamin K deficiency - Aspirin increases the chance of serious
bleeding
-
Stomach ulcer, especially with a history of bleeding, or other stomach
problems - Aspirin can make your condition worse
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