Cevimeline (Systemic)

Brand Names : Evoxac

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cevimeline, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to cevimeline. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Cevimeline has not been studied in women who are pregnant. However, in animal studies, cevimeline caused a reduction in the number of pregnancies. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding - It is not known whether cevimeline passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children - Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of cevimeline in children with use in other age groups.

Older adults - Older adults - Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cevimeline in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking cevimeline, it is especially important that your doctor and pharmacist know if you are taking any of the following:

• Beta-adrenergic blocking agents (acebutolol, [e.g. Sectral], atenolol [e.g. Tenormin], betaxolol [e.g. Kerlone], carteolol [e.g. Cartrol], labetolol [e.g. Normodyne], metoprolol [e.g. Lopressor], nadolol [e.g. Corgard], oxprenolol [e.g. Trasicor], penbutolol [e.g. Levatol], pindolol [e.g. Visken], propranolol [e.g.Inderal], sotalol [e.g. Sotacor], timolol [e.g. Blocadren]) - Disturbances in heart rhythms may occur if these medicines are taken with cevimeline.
• Anticholinergics (medicine for abdominal or stomach spasms or cramps) - Cevimeline may interfere with the effects of these medicines.
• Cholinergics (bethanechol [e.g.Duvoid], donepezil [e.g. Tacrine], physostigmine [e.g. Antilirium], pilocarpine [e.g. Pilocar], pyridostigmine [e.g. Mestinon] - These medicines can add to the effects of cevimeline.

. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.�

Other medical problems - The presence of other medical problems may affect the use of cevimeline. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma, uncontrolled, or
• Cholelithiasis (gallstones), or
• Heart disease, or
• Nephrolithiasis (kidney stones), or
• Eye conditions in which contraction of the pupils is undesirable (e.g., acute iritis and narrow-angle glaucoma), or
• Pulmonary disease other than asthma