Chlorambucil (Systemic)

Brand Names : Leukeran

Side Effects of This Medicine

Along with its needed effects, a medicine may have some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor or nurse immediately if any of the following side effects occur:

More Common

Black, tarry stools; blood in urine or stools; cough or hoarseness, accompanied by fever or chills; fever or chills; lower back or side pain, accompanied by fever or chills; painful or difficult urination, accompanied by fever or chills; pinpoint red spots on skin; unusual bleeding or bruising

Less common

Large, swollen hives; itching; skin rash; sores in mouth and on lips

Rare

Cough; blisters on skin; muscle twitching or jerking; shortness of breath

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Joint pain; swelling of feet or lower legs

Rare

Agitation; confusion; convulsions (seizures); hallucinations (seeing, hearing, or feeling things that are not there); tremors; trouble in walking; weakness (severe) or paralysis; yellow eyes or skin

Symptoms of overdose (in the order of frequency)

Black, tarry stools; blood in urine or stools; cough or hoarseness, accompanied by fever or chills; fever or chills; lower back or side pain, accompanied by fever or chills; painful or difficult urination, accompanied by fever or chills; pinpoint red spots on skin; unusual bleeding or bruising; agitation; convulsions (seizures); trouble in walking

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Changes in menstrual period; itching of skin; nausea and vomiting

After you stop using chlorambucil, it may still produce some side effects that need attention. During this period of time, check with your doctor if you notice any of the following side effects:

Black, tarry stools; blood in urine or stools; cough or hoarseness (may be accompanied by fever or chills); fever or chills; lower back or side pain, accompanied by fever or chills; painful or difficult urination, accompanied by fever or chills; pinpoint red spots on skin; shortness of breath; unusual bleeding or bruising

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.