Clodronate (Systemic)

Brand Names : Bonefos, disodium clodronate

Proper Use of This Medicine

Dosing - The dose of clodronate will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of clodronate. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking clodronate.

• For oral dosage form :
  • For treating hypercalcemia (too much calcium in the blood):
    • Adults - 1600 milligrams (mg) to 2400 mg given in one or two divided amounts per day. Your doctor may give you capsules after you have had clodronate through your vein. You should not take more than 3200 mg in a day. You should take clodronate at least two hours before or after food.
    • Children - Use and dosage must be determined by your doctor.
  For injection dosage form:
  • For treating hypercalcemia (too much calcium in the blood):
    • Adults - 300 mg in a solution to be injected over at least two hours into a vein once a day for two to five days. The treatment will not be longer than seven days. The amount of medicine may be less if you have kidney problems.
    • Children - Use and dosage must be determined by your doctor.

Storage - To store this medicine:

• Keep out of the reach of children. Overdose of clodronate is very dangerous in young children.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.