Cocaine (Mucosal-Local)

Before Receiving This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cocaine, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to cocaine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Studies on birth defects or other problems have not been done in pregnant women receiving cocaine as a local anesthetic. However, studies in women who abused cocaine during pregnancy have shown that cocaine may cause birth defects, decreased birth weight and size, and problems affecting the baby's nervous system. These studies have also shown that too much use of cocaine may cause the baby to be born too soon, sometimes too soon to survive. Cocaine has also been shown to cause birth defects and other unwanted effects in animal studies.

Breast-feeding - Cocaine passes into the breast milk and may cause unwanted effects such as convulsions (seizures), high blood pressure, fast heartbeat, breathing problems, trembling, and unusual irritability in nursing babies. Therefore, after receiving this medicine you should stop breast-feeding your baby for about 2 days.

Children - Cocaine can cause serious side effects in any patient. Therefore, it is especially important that you discuss with the child's doctor the good that this medicine may do as well as the risks of using it.

Older adults - Side effects, including dizziness or lightheadedness or fast or irregular heartbeat, may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of cocaine.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving cocaine, it is especially important that your health care professional know if you are taking any of the following:

• Amantadine (e.g., Symmetrel) or
• Amphetamines or
• Antimyasthenics (ambenonium [e.g., Mytelase], neostigmine [e.g., Prostigmin], pyridostigmine [e.g., Mestinon]) or
• Appetite suppressants (diet pills), except fenfluramine (e.g., Pondimin), or
• Beta-blockers (acebutolol [e.g., Sectral], atenolol [e.g., Tenormin], betaxolol [e.g., Kerlone], carteolol [e.g., Cartrol], labetalol [e.g., Normodyne], metoprolol [e.g., Lopressor], nadolol [e.g., Corgard], oxprenolol [e.g., Trasicor], penbutolol [e.g., Levatol], pindolol [e.g., Visken], propranolol [e.g., Inderal], sotalol [e.g., Sotacor], timolol [e.g., Blocadren]) or
• Betaxolol (ophthalmic) (e.g., Betoptic) or
• Caffeine (e.g., NoDoz) or
• Chlophedianol (e.g., Ulone) or
• Cyclophosphamide (e.g., Cytoxan) or
• Demecarium (e.g., Humorsol) or
• Echothiophate (e.g., Phospholine Iodide) or
• Guanadrel (e.g., Hylorel) or
• Guanethidine (e.g., Ismelin) or
• Isoflurophate (e.g., Floropryl) or
• Levobunolol (e.g., Betagan) or
• Levodopa (e.g., Dopar) or
• Malathion (e.g., Prioderm) or
• Medicine for asthma or other breathing problems or
• Medicine for colds, sinus problems, or hay fever or other allergies (including nose drops or sprays) or
• Methyldopa (e.g., Aldomet) or
• Methylphenidate (e.g., Ritalin) or
• Metipranolol (e.g., OptiPranolol) or
• Nabilone (e.g., Cesamet) or
• Pemoline (e.g., Cylert) or
• Thiotepa or
• Timolol (ophthalmic) (e.g., Timoptic) - The chance of serious side effects may be increased

• Monoamine oxidase (MAO) inhibitors (furazolidone [e.g., Furoxone], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate]) - Receiving cocaine while you are taking or within 2 weeks after you have taken an MAO inhibitor may increase the chance of serious side effects.

Also tell your doctor if you have recently used an insecticide (insect killer) or if you have been in an area that was recently treated with an insecticide. Some insecticides can slow the breakdown of cocaine in your body. This increases the chance of serious side effects.

Other medical problems - The presence of other medical problems may affect the use of cocaine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cancer or
• Chest pain, or history of, or
• Convulsions (seizures), history of, or
• Fast or irregular heartbeat or
• Heart or blood vessel disease or
• High blood pressure or
• Liver disease or
• Myocardial infarction (``heart attack''), history of, or
• Overactive thyroid - The chance of serious side effects may be increased

• Tourette's syndrome - Cocaine can make your condition worse