Dactinomycin (Systemic)

Brand Names : Cosmegen, actinomycin-D

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools; blood in urine or stools; cough or hoarseness accompanied by fever or chills; fever or chills; lower back or side pain accompanied by fever or chills; painful or difficult urination accompanied by fever or chills; pinpoint red spots on skin; unusual bleeding or bruising

Rare

Pain at place of injection; wheezing

Check with your health care professional as soon as possible if any of the following side effects occur:

More common

Diarrhea (continuing); difficulty in swallowing; heartburn; sores in mouth and on lips; stomach pain (continuing); unusual tiredness or weakness

Rare

Joint pain; swelling of feet or lower legs; yellow eyes or skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Darkening of skin; infection; unusual feeling of dullness or sluggishness; general feeling of discomfort or weakness; nausea and vomiting; redness of skin; skin rash or acne

This medicine often causes a temporary loss of hair, sometimes including the eyebrows. After treatment with dactinomycin has ended, normal hair growth should return.

After you stop receiving dactinomycin, it may still produce some side effects that need attention. During this period of time check with your doctor if you notice any of the following:

Black, tarry stools; blood in urine or stools; cough or hoarseness accompanied by fever or chills; diarrhea; fever or chills; lower back or side pain accompanied by fever or chills; painful or difficult urination accompanied by fever or chills; pinpoint red spots on skin; sores in mouth and on lips; stomach pain; unusual bleeding or bruising; yellow eyes or skin

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.