Dinoprostone (Cervical/Vaginal)

Brand Names : Cervidil, Prepidil, Prostin E, prostaglandin E 2, PGE 2

Proper Use of This Medicine

After dinoprostone is given, you will need to lie down for 10 minutes to 2 hours so that the medicine can be absorbed. The length of time you must remain lying down will depend on what form of the medicine you are using.

Dosing - The dose of dinoprostone will be different for different patients. The following information includes only the average doses for dinoprostone. Your doctor will give you the dose of this medicine and follow your care in a hospital or other health care setting.

• For cervical dosage form (gel):
  • To thin and widen the opening of the cervix just before labor:
    • Adults and teenagers - Your doctor will insert 0.5 milligram (mg) (one application) of dinoprostone into the canal of your cervix. You should remain lying on your back for at least ten to thirty minutes after it has been applied.
• For vaginal dosage form (gel):
  • To cause the uterus to contract for labor:
    • Adults and teenagers - Your doctor will insert 1 milligram (mg) (one applicatorful) of dinoprostone into your vagina. You should remain lying on your back for at least thirty minutes after it has been applied. You may need another dose of 1 to 2 mg six hours after the first dose.
• For vaginal dosage form (suppositories):
  • To cause the uterus to contract to abort a pregnancy:
    • Adults and teenagers - Your doctor will insert 20 milligrams (mg) (one suppository) into your vagina every three to five hours as needed. You should remain lying on your back for at least ten minutes after it has been inserted.
• For vaginal dosage form (system):
  • To thin and widen the opening of the cervix just before labor:
    • Adults and teenagers - Your doctor will insert 10 milligrams (mg) (one system) into your vagina. You should remain lying on your back for at least two hours after it has been inserted.