Gonadorelin (Systemic)

Brand Names : Factrel, Lutrepulse, Relisorm, luteinizing hormone–releasing hormone, luteinizing hormone–releasing factor dihydrochloride, luteinizing hormone–releasing factor diacetate tetrahydrate, luteinizing hormone–/follicle-stimulating hormone–releasing hormone

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For gonadorelin, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to gonadorelin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Gonadorelin has not been shown to cause birth defects or problems in humans when given in the first three months of pregnancy. If you become pregnant while using this medicine, there is an increased chance of a multiple pregnancy, such as having twins and triplets. Also, gonadorelin has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding - It is not known if gonadorelin passes into the breast milk. Gonadorelin has not been reported to cause problems in nursing babies.

Children - Gonadorelin, used as a test, has been studied only in children 12 years of age and older. The medicine has not caused different side effects or problems in children 12 years of age and older than it does in adults. Children up to 12 years of age may not be sensitive to the effects of gonadorelin. Infants may be very sensitive to the effects of gonadorelin and use in infants is not recommended.

Adolescents - Gonadorelin has been tested in a limited number of teenagers and, in effective doses, has not been shown to cause different side effects or problems in teenagers than it does in adults.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using gonadorelin, it is especially important that your health care professional know if you are taking any of the following:

• Infertility therapy agents, such as clomiphene (e.g., Clomid) - When using gonadorelin to cause ovulation, the use of other infertility therapy agents at the same time may increase the chance of causing problems of the ovaries

Other medical problems - The presence of other medical problems may affect the use of gonadorelin. Make sure you tell your doctor if you have any other medical problems, especially:

• Gonadotropin-releasing hormone adenoma - Although this condition is rare, use of gonadorelin when this condition exists may cause problems in the pituitary gland and could result in sudden blindness
• Any condition that may be made worse by estrogens, progestins, or androgens, such as a hormone-dependent tumor - The increase of estrogens and progestins in women or androgens in men that can result from use of multiple doses of gonadorelin may make a tumor worse if the tumor depends on estrogens, progestins, or androgens for growth