Idarubicin (Systemic)

Brand Names : Idamycin

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For idarubicin, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to idarubicin.

Pregnancy - There is a chance that this medicine may cause birth defects if either the male or female is receiving it at the time of conception or if it is taken during pregnancy. Studies in rats and rabbits have shown that idarubicin causes birth defects in the fetus and other problems (including miscarriage). In addition, many cancer medicines may cause sterility which could be permanent. Although sterility has been reported only in male dogs with this medicine, the possibility of an effect in human males should be kept in mind.

Be sure that you have discussed these possible effects with your doctor before receiving this medicine. It is best to use some kind of birth control while you are receiving idarubicin. Tell your doctor right away if you think you have become pregnant while receiving idarubicin. Before receiving idarubicin make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding - Because idarubicin may cause serious side effects, breast-feeding is generally not recommended while you are receiving it.

Children - There is no specific information comparing use of idarubicin in children with use in other age groups.

Older adults - Heart problems are more likely to occur in the elderly, who are usually more sensitive to the effects of idarubicin.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving idarubicin, it is especially important that your health care professional know if you have ever been treated with x-rays or cancer medicines or if you are taking any of the following:

• Amphotericin B by injection (e.g., Fungizone) or
• Antithyroid agents (medicine for overactive thyroid) or
• Azathioprine (e.g., Imuran) or
• Chloramphenicol (e.g., Chloromycetin) or
• Colchicine or
• Flucytosine (e.g., Ancobon) or
• Ganciclovir (e.g., Cytovene) or
• Interferon (e.g., Intron A, Roferon-A) or
• Plicamycin (e.g., Mithracin) or
• Zidovudine (e.g., AZT, Retrovir) - Idarubicin may increase the effects of these medicines or radiation therapy on the blood

• Probenecid (e.g., Benemid) or
• Sulfinpyrazone (e.g., Anturane) - Idarubicin may raise the concentration of uric acid in the blood, which these medicines are used to lower

Other medical problems - The presence of other medical problems may affect the use of idarubicin. Make sure you tell your doctor if you have any other medical problems, especially:

• Chickenpox (including recent exposure) or
• Herpes zoster (shingles) - Risk of severe disease affecting other parts of the body

• Gout or
• Kidney stones - Idarubicin may increase levels of a chemical called uric acid in the body, which can cause gout or kidney stones

• Heart disease - Risk of heart problems caused by idarubicin may be increased

• Kidney disease or
• Liver disease - Effects may be increased because of slower removal of idarubicin from the body