Isometheptene, Dichloralphenazone, and Acetaminophen (Systemic)

Brand Names : Midchlor, Midrin, Migrapap, Migquin, Migratine, Migrazone, Migrend, Migrex, Mitride, Amidrine, Duradrin, I.D.A, Iso-Acetazone, Isocom

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this combination medicine, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to acetaminophen or to this combination medicine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Studies with this combination medicine have not been done in either humans or animals.

Breast-feeding - Acetaminophen passes into the breast milk in small amounts. However, this medicine has not been shown to cause problems in nursing babies.

Children - Studies with this medicine have been done only in adult patients, and there is no specific information about its use in children.

Older adults - Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this combination medicine in the elderly with use in other age groups.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this combination medicine, it is especially important that your health care professional know if you are taking any of the following:

• Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate]) - Taking this combination medicine while you are taking or within 2 weeks of taking a monoamine oxidase (MAO) inhibitor may increase the chance of side effects

Other medical problems - The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse or
• Heart attack (recent) or
• Heart or blood vessel disease or
• Kidney disease or
• Liver disease or
• Stroke (recent) or
• Virus infection of the liver (viral hepatitis) - The chance of side effects may be increased

• Glaucoma, not well controlled, or
• High blood pressure (hypertension), not well controlled - The isometheptene in this combination medicine may make these conditions worse