Methoxsalen (Systemic)

Brand Names : 8-MOP, Oxsoralen-Ultra, Oxsoralen, Ultra MOP

Before Using This Medicine

Methoxsalen is a very strong medicine that increases the skin's sensitivity to sunlight. In addition to causing serious sunburns if not properly used, it has been reported to increase the chance of skin cancer and cataracts. Also, like too much sunlight, PUVA can cause premature aging of the skin. Therefore, methoxsalen should be used only as directed and it should not be used simply for suntanning. Before using this medicine, be sure that you have discussed its use with your doctor.

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For methoxsalen, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to methoxsalen. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Diet - Eating certain foods while you are taking methoxsalen may increase your skin's sensitivity to sunlight. To help prevent this, avoid eating limes, figs, parsley, parsnips, mustard, carrots, and celery while you are being treated with this medicine.

Pregnancy - Studies on effects in pregnancy have not been done in either humans or animals.

Breast-feeding - It is not known whether methoxsalen passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are using this medicine and who wish to breast-feed should discuss this with their doctor.

Children - Some of the side effects are more likely to occur in children up to 12 years of age, since these children may be more sensitive to the effects of methoxsalen.

Older adults - Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of methoxsalen in the elderly with use in other age groups.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using methoxsalen, it is especially important that your health care professional know if you are using the following:

• Arsenicals or recent treatment with x-rays, or cancer medicines or plans to have x-rays in the near future - Arsenicals, x-rays and cancer medicines increase the chance of side effects from treatment with PUVA

Other medical problems - The presence of other medical problems may affect the use of methoxsalen. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to sunlight (or family history of) or
• Infection or
• Lupus erythematosus or
• Porphyria or
• Skin cancer (history of) or
• Skin conditions (other) or
• Stomach problems - Use of PUVA may make the condition worse

• Eye problems, such as cataracts or loss of the lens of the eye - The light treatment may make the condition worse or may cause damage to the eye

• Heart or blood vessel disease (severe) - The heat or prolonged standing associated with each light treatment may make the condition worse

• Liver disease - Condition may cause increased blood levels of the medicine and cause an increase in side effects