Mitotane (Systemic)

Brand Names : Lysodren

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mitotane, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to mitotane. Also tell your health care professional if you are allergic to any other substance, such as foods, preservatives, or dyes.

Pregnancy - Mitotane has not been shown to cause problems in humans.

Breast-feeding - Although it is not known whether mitotane passes into the breast milk, it has not been reported to cause problems in nursing babies.

Children - Although there is no specific information about the use of mitotane in children, it is not expected to cause different side effects or problems in children than it does in adults.

Older adults - Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information about the use of mitotane in the elderly.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking mitotane, it is especially important that your health care professional know if you are taking any of the following:

• Central nervous system (CNS) depressants - CNS depressant effects may be increased

Other medical problems - The presence of other medical problems may affect the use of mitotane. Make sure you tell your doctor if you have any other medical problems, especially:

• Infection

• Liver disease - Effects may be increased because of slower removal of mitotane from the body