Pamidronate (Systemic)

Brand Names : Aredia, APD

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Abdominal cramps; black, tarry stools; bleeding gums; bloody in urine or stools; blurred vision; chest pain; chills; confusion; convulsions (seizures); decrease in amount of urine; dizziness; drowsiness; dry mouth; fainting; fast or irregular heartbeat; fever; headache; increased thirst; loss of appetite; mood or mental changes; muscle pain or cramps; muscle spasms; muscle twitching; nausea; nervousness; noisy, rattling breathing; numbness or tingling in hands, feet, or lips;; pinpoint red spots on skin; pounding in the ears; shortness of breath; slow or fast heartbeat; spread of cancer; sore throat; swelling of fingers, hands, feet, or lower legs; trembling; troubled breathing at rest; unusual bleeding or bruising; unusual tiredness or weakness; vomiting; vomiting of blood or material that looks like coffee grounds; weight gain

Note:

Abdominal cramps, confusion, and muscle spasms are less common when pamidronate is given in doses of 60 mg or less.

Less common

Cough; dilated neck veins; extreme fatigue; irregular breathing; lower back or side pain; painful or difficult urination; pale skin; swelling; ulcers, sores, or white spots in mouth; wheezing

Rare

Decreased vision; difficulty swallowing; eye pain or tenderness; eye redness; hives; itching; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; sensitivity of eye to light; skin rash; sweating; tearing of eye; tightness in chest

Frequency not determined

faintness, or light-headedness when getting up from a lying or sitting position suddenly; hives; itching of the skin; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; skin rash; tightness in chest

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Abdominal pain; acid or sour stomach; belching; bladder pain; bloody or cloudy urine; body aches or pain; bone pain; cracks in skin at the corners of mouth; constipation; degenerative disease of the joint; diarrhea; difficult, burning, or painful urination; difficult or labored breathing; difficulty in moving; ear congestion; fear; frequent urge to urinate; general feeling of body discomfort or illness; heartburn; indigestion; joint pain; lack or loss of strength; loss of voice; lower back or side pain; muscle aching or cramping; muscle pains or stiffness; nasal congestion; nervousness; pain and swelling at place of injection; pain or tenderness around eyes and cheekbones; runny nose; sensitivity to heat; shivering; skin rash; sleeplessness; small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope; sneezing; soreness or redness around fingernails and toenails; stomach discomfort, upset or pain; stuffy nose; sweating; swollen joints; trouble sleeping; ulcers, sores, or white spots in mouth; unable to sleep; weight loss

Less common

Ammonia-like breath odor; feeling that others are watching you or controlling your behavior; feeling that others can hear your thoughts; feeling, seeing, or hearing things that are not there; feeling unusually cold; swelling or inflammation of the mouth; unusual behavior

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.