Pyrazinamide (Systemic)

Brand Names : pms-Pyrazinamide, Tebrazid

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pyrazinamide, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to pyrazinamide or to ethionamide (e.g., Trecator-SC), isoniazid (e.g., INH, Nydrazid), or niacin (e.g., Nicobid, nicotinic acid). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Studies on effects in pregnancy have not been done in either humans or animals.

Breast-feeding - Pyrazinamide passes into the breast milk in small amounts.

Children - Pyrazinamide has been used in children and, in effective doses, has not been reported to cause different side effects or problems in children than it does in adults.

Older adults - Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing pyrazinamide in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems - The presence of other medical problems may affect the use of pyrazinamide. Make sure you tell your doctor if you have any other medical problems, especially:

• Gout (history of) - Pyrazinamide may worsen or cause a gout attack in patients with a history of gout

• Liver disease (severe) - Patients with severe liver disease who take pyrazinamide may have an increase in side effects