Rosiglitazone and Metformin (Systemic)

Brand Names : Avandamet

Proper Use of This Medicine

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Rosiglitazone and metformin combination should be taken with meals to help reduce the stomach and intestinal side effects that may occur while you are taking this medicine.

You may notice improvement in your blood glucose control in 1 to 2 weeks but the full effect of blood glucose control may take up to 2 to 3 months. Ask your healthcare professional if you have any questions about this.

Dosing - The dose of rosiglitazone and metformin will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of rosiglitazone and metformin. If your dose is different, do not change it unless your doctor tells you to do so.

• For oral dosage form (tablets):
  • For type 2 diabetes:
    • For patients on metformin therapy
      • Adults: Oral, 4 milligrams (mg) rosiglitazone plus the dose of metformin already being taken. Your doctor may gradually increase your dose until your blood sugar is controlled.
      • Children: Use and dose must be determined by your doctor.
    • For patients on rosiglitazone therapy:
      • Oral, 1000 milligrams (mg) of metformin plus the dose of rosiglitazone already being taken. Your doctor may gradually increase your dose until your blood sugar is controlled.
      • Children: Use and dose must be determined by your doctor.
    • For patients previously treated rosiglitazone and metformin:
      • Adults: Oral, the dose is the same as the dose you are already taking. Your doctor may gradually increase your dose until your blood sugar is controlled.
      • Children: Use and dose must be determined by your doctor.

Missed dose - If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage - To store this medicine:

• Keep out of the reach of children.
• Keep the medicine from freezing. Do not refrigerate.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.