Selegiline (Systemic)

Brand Names : Carbex, Eldepryl, Apo-Selegiline, Gen-Selegiline, Novo-Selegiline, Nu-Selegiline, SD Deprenyl, Selegiline-5, deprenil, deprenyl

Side Effects of This Medicine

When you start taking selegiline in addition to levodopa or carbidopa and levodopa combination, you may experience an increase in side effects. If this occurs, your doctor may gradually reduce the amount of levodopa or carbidopa and levodopa combination you take.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following side effects occur:

Symptoms of unusually high blood pressure (caused by reaction of higher than usual doses of selegiline with restricted foods or medicines)

Chest pain (severe); enlarged pupils; fast or slow heartbeat; headache (severe); increased sensitivity of eyes to light; increased sweating (possibly with fever or cold, clammy skin); nausea and vomiting (severe); stiff or sore neck

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Increase in unusual movements of body; mood or other mental changes

Less common or rare

Bloody or black, tarry stools; difficult or frequent urination; difficulty in breathing; difficulty in speaking; dizziness or lightheadedness, especially when getting up from a lying or sitting position; hallucinations (seeing, hearing, or feeling things that are not there); irregular heartbeat; lip smacking or puckering; loss of balance control; puffing of cheeks; rapid or worm-like movements of tongue; restlessness or desire to keep moving; severe stomach pain; swelling of feet or lower legs; tightness in chest; twisting movements of body; uncontrolled chewing movements; uncontrolled movements of face, neck, back, arms or legs; vomiting of blood or material that looks like coffee grounds; wheezing

Symptoms of overdose

Agitation or irritability; chest pain; convulsions (seizures); difficulty opening mouth or lockjaw; dizziness (severe) or fainting; fast or irregular pulse (continuing); high fever; high or low blood pressure; increased sweating (possibly with fever or cold, clammy skin); severe spasm where the head and heels are bent backward and the body arched forward; troubled breathing

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Abdominal or stomach pain; dizziness or feeling faint; dryness of mouth; nausea; trouble in sleeping; vomiting

Less common or rare

Anxiety; back or leg pain; blurred or double vision; body ache; burning of lips, mouth, or throat; chills; constipation; diarrhea; drowsiness; headache; heartburn; high or low blood pressure; inability to move; frequent urge to urinate; increased sensitivity of skin to light; increased sweating; irritability (temporary); loss of appetite; memory problems; muscle cramps; nervousness; numbness of fingers or toes; pounding or fast heartbeat; red, raised, or itchy skin; restlessness; ringing or buzzing in ears; slow or difficult urination; slowed movements; taste changes; uncontrolled closing of eyelids; unusual feeling of well-being; unusual tiredness or weakness; unusual weight loss

With doses higher than 10 mg a day

Clenching, gnashing, or grinding teeth; sudden jerky movements of body

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.