Ticlopidine (Systemic)

Brand Names : Ticlid

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ticlopidine, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to ticlopidine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Studies with ticlopidine have not been done in pregnant women. This medicine did not cause birth defects in animal studies. However, it caused other unwanted effects in animal studies when it was given in amounts that were large enough to cause harmful effects in the mother.

Breast-feeding - It is not known whether ticlopidine passes into the breast milk.

Children - There is no specific information comparing use of ticlopidine in children with use in other age groups.

Older adults - This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ticlopidine, it is especially important that your health care professional know if you are taking any of the following:

• Anticoagulants (blood thinners) or
• Aspirin or
• Carbenicillin by injection (e.g., Geopen) or
• Clopidogrel (e.g., Plavix) or
• Dipyridamole (e.g., Persantine) or
• Divalproex (e.g., Depakote) or
• Heparin (e.g., Hepalean, Liquaemin) or
• Inflammation or pain medicine, except narcotics or
• Low molecular weight heparin (ardeparin [e.g., Normiflo], dalteparin [e.g., Fragmin], enoxaparin [e.g., Lovenox], nadroparin [e.g., Fraxiparine]) or
• Pentoxifylline (e.g., Trental) or
• Plicamycin (e.g., Mithracin) or
• Sulfinpyrazone (e.g., Anturane) or
• Ticarcillin (e.g., Ticar) or
• Valproic acid (e.g., Depakene) - The chance of serious bleeding may be increased

• Phenytoin (e.g., Dilantin) - Ticlopidine may increase the amount of phenytoin in the blood and increase the chance of side effects from phenytoin
• Xanthines such as theophylline (e.g. Theo-Dur) - Ticlopidine may slow the elimination of theophylline and increase the chance of side effects from theophylline

Other medical problems - The presence of other medical problems may affect the use of ticlopidine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood clotting problems, such as hemophilia and von Willebrand's disease, or
• Liver disease (severe) or
• Stomach ulcers - The chance of serious bleeding may be increased

• Blood disease - The chance of serious side effects may be increased

• Kidney disease (severe) - Ticlopidine is removed from the body more slowly when the kidneys are not working properly. This may increase the chance of side effects

Also, tell your doctor if you have ever had a problem called thrombotic thrombocytopenic purpura (TTP). This problem could reoccur if you take ticlopidine.