Trilostane (Systemic)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trilostane, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to trilostane. Also tell your health care professional if you are allergic to any other substance, such as foods, preservatives, or dyes.

Pregnancy - Use of trilostane is not recommended during pregnancy. It has been shown to cause serious problems, including miscarriage, in humans. Trilostane has also been shown to cause birth defects in animals.

Breast-feeding - It is not known whether trilostane passes into breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Children - There is no specific information about the use of trilostane in children.

Older adults - Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information about the use of trilostane in the elderly.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking trilostane, it is especially important that your health care professional know if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems - The presence of other medical problems may affect the use of trilostane. Make sure you tell your doctor if you have any other medical problems, especially:

• Infection or
• Injury (recent serious) - Trilostane may weaken the body's normal defenses

• Kidney disease

• Liver disease