Piperacillin/Tazobactam (Injection) (Zosyn) - Drugs Information, Side Effects, & Interactions

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Piperacillin (pi-PER-a-sil-in), Tazobactam (ta-zoe-BAK-tam)

Treats infections. Belongs to a class of drugs called penicillin antibiotics.

Zosyn
There may be other brand names for this medicine.

You should not use this medicine if you have ever had an allergic reaction to piperacillin or any penicillin medicine.

Injectable

Your doctor will prescribe your exact dose and tell you how often it should be given.
An IM injection is a shot given in your muscle (upper arm, thigh, buttocks). An IV infusion is medicine that is put directly into your body through one of your veins.
This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or friend can be taught to give your medicine.
If you are receiving IV medicine, check the bag to make sure there are no leaks. Also make sure the solution is clear.

If a dose is missed:

This medicine needs to be given on a regular schedule. Take the missed dose as soon as you remember, and take the rest of the doses for the day at regularly spaced time intervals.
If you miss more than one dose, call your doctor for instructions.

Store the medicine in a refrigerator. Do not freeze. Take it out of the refrigerator an hour before the time for your next dose and allow it to warm to room temperature in a clean, dry place.
If you see particles in the solution, You should not use it.
If you have your treatments at home, you should be given a special container for the used needles. Keep it where children or pets cannot reach it.
Keep all medicine out of the reach of children.

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Make sure your doctor knows if you are taking probenecid before you take this medicine.
Birth control pills may not work as well while taking piperacillin/tazobactam. Use another kind of birth control while you are taking this medicine.

Make sure your doctor knows if you have ever had an allergic reaction to any cephalosporin antibiotic such as Keflex® or Ceclor® before you take piperacillin/tazobactam.
Make sure your doctor knows if you have mononucleosis (mono), stomach or intestinal disease, asthma, liver disease, hay fever, or other allergies before you take this medicine.
If your infection does not improve, or if it gets worse while taking this medicine, talk to your doctor.
If you have severe diarrhea while taking piperacillin/tazobactam, check with your doctor before taking medicine to stop the diarrhea.
If you are pregnant or breastfeeding, talk to your doctor before taking piperacillin/tazobactam.

Call your doctor right away if you notice any of these side effects:

If you notice these less serious side effects, talk with your doctor:

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