Salsalate (By Mouth)

Salsalate (SAL-sa-late)

Treats pain, fever, and arthritis. Belongs to a group of drugs called salicylates.

Brand Name(s):

Amigesic, Salflex, Mono-Gesic
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to salsalate, aspirin, or pain and arthritis medicine such as Motrin® or Aleve®. Salsalate should not be given to children or teenagers with fever, symptoms of the flu, chicken pox, or viral infection. You should not use this medicine if you have an active ulcer or bleeding problem.

How to Use This Medicine:

Capsule, Tablet

• Your doctor will tell you how much to take and how often.
• Swallow the pill whole; do not crush, break, or chew.
• Take this medicine with food or milk to avoid stomach upset.

If a dose is missed:

• May be taken as soon as possible.
• Skip the missed dose if it is almost time for your next dose.
• You should not use two doses at the same time.

How to Store and Dispose of This Medicine:

• Store in a tightly closed container at room temperature, away from heat, direct light, or moisture.
• Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Avoid drinking alcohol while taking salsalate.
• Make sure your doctor knows if you are taking blood-thinners (Coumadin®), probenecid, cortisone medicine (prednisone), or methotrexate.

Warnings While Using This Medicine:

• Check with your doctor before taking if you are pregnant or breastfeeding, or if you have asthma, kidney problems or a history of ulcers.
• Salsalate may cause incorrect results with some urine sugar tests used by patients with diabetes.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Severe stomach pain
• Brown or red, grainy vomit
• Blood in stools or urine
• Skin rash or hives with intense itching
• Swelling in the face or eyelids
• Wheezing or trouble breathing
• Severe dizziness or drowsiness
• Ringing in the ears

If you notice these less serious side effects, talk with your doctor:

• Upset stomach
• Heartburn

If you notice other side effects that you think are caused by this medicine, tell your doctor.