Simvastatin (By Mouth)

Simvastatin (SIM-va-stat-in)

Lowers high levels of cholesterol.

Brand Name(s):

Zocor
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to simvastatin, or to similar medicines such as atorvastatin (Lipitor®), cerivastatin (Baycol®), fluvastatin (Lescol®), lovastatin (Mevacor®), or pravastatin (Pravachol®). You should not use this medicine if you are pregnant, breastfeeding, or have liver disease.

How to Use This Medicine:

Tablet

• Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to. Take the medicine in the evening, unless your doctor tells you otherwise.
• You may take the medicine with or without food. Carefully follow your doctor's instructions about diet and exercise.

If a dose is missed:

• If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.
• Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

• Store the medicine at room temperature, away from heat, moisture, and direct light.
• Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
• Keep all medicine out of the reach of children and never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are also using blood thinners (Coumadin®), cyclosporine (Neoral®, Sandimmune®), digoxin (Lanoxin®), erythromycin, gemfibrozil (Lopid®), niacin, nefazodone (Serzone®), or an antibiotic such as fluconazole (Diflucan®), itraconazole (Sporanox®), or ketoconazole (Nizoral®).
• Do not drink alcohol while you are taking this medicine.
• Do not eat grapefruit or drink grapefruit juice while taking this medicine.

Warnings While Using This Medicine:

• Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
• Make sure your doctor knows if you have liver disease, kidney disease, or a muscle disorder.
• Tell your doctor if you usually drink large amounts of alcohol.
• Make sure any doctor or dentist who treats you knows that you are using this medicine.
• Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
• Do not stop using this medicine without asking your doctor. You may need a special diet to keep your cholesterol levels from going up after you stop using the medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Muscle pain, weakness, or cramps
• Skin rash or hives
• Stomach pain, nausea, vomiting, loss of appetite
• Unexplained fever
• Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

• Constipation or diarrhea
• Headache
• Mild stomach upset, gas, indigestion

If you notice other side effects that you think are caused by this medicine, tell your doctor.