Serum Sickness

What are the treatments for the condition?

The most important treatment is to stop taking the substance that caused the serum sickness. Antihistamines, such as diphenhydramine, may be given to reduce itching and other uncomfortable symptoms. Corticosteroids, such as hydrocortisone, may also be given to reduce inflammation. This may be given as a pill or as a skin cream for a rash. Both of these treatments may lessen the duration or intensity of the illness. Pain medications, such as acetaminophen, can be given for joint pain.

What are the side effects of the treatments?

Antihistamines can cause dry mouth and drowsiness. Corticosteroid creams in some cases can thin the skin and cause lighter colored areas to form. Corticosteroid pills can cause weight gain, stomach upset, and other side effects.

What happens after treatment for the condition?

A person with serum sickness usually recovers completely within a week. The medication or other substance that caused serum sickness should not be taken again, even years later. In rare cases, nerve or kidney damage may occur and require ongoing treatment.

How is the condition monitored?

Any new or worsening symptoms should be reported to the healthcare provider.