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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Antihistamines and Decongestants

Antihistamines and Decongestants (Systemic)

Description and Brand Names | Before Using | Proper Use | Precautions | Side Effects

Category
  • Antihistaminic (H 1 -receptor)-decongestant - Acrivastine and Pseudoephedrine; Azatadine and Pseudoephedrine; Brompheniramine and Pseudoephedrine; Carbinoxamine and Pseudoephedrine; Cetirizine and Pseudoephedrine; Chlorpheniramine and Phenylephrine; Chlorpheniramine and Pseudoephedrine; Chlorpheniramine, Phenyltoloxamine, and Phenylephrine; Chlorpheniramine, Pyrilamine, and Phenylephrine; Dexbrompheniramine and Pseudoephedrine; Diphenhydramine and Pseudoephedrine; Loratadine and Pseudoephedrine; Pheniramine and Phenylephrine; Promethazine and Phenylephrine; Triprolidine and Pseudoephedrine
Description

Antihistamine and decongestant combinations are used to treat the nasal congestion (stuffy nose), sneezing, and runny nose caused by colds and hay fever.

Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Antihistamines contained in these combinations are:

acrivastine, azatadine, brompheniramine, carbinoxamine, chlorpheniramine, clemastine, dexbrompheniramine, diphenhydramine, loratadine, pheniramine, phenyltoloxamine, promethazine, pyrilamine, and triprolidine.

The decongestants, such as phenylephrine, and pseudoephedrine, produce a narrowing of blood vessels. This leads to clearing of nasal congestion, but it may also cause an increase in blood pressure in patients who have high blood pressure.

Some of these combinations are available only with your doctor's prescription. Others are available without a prescription; however, your doctor may have special instructions on the proper dose of the medicine for your medical condition. They are available in the following dosage forms:

    Oral
  • Acrivastine and Pseudoephedrine
    • Capsules (U.S.)
  • Azatadine and Pseudoephedrine
    • Extended-release tablets (U.S. and Canada)
  • Brompheniramine and Pseudoephedrine
    • Extended-release capsules (U.S.)
    • Oral solution (U.S.)
    • Syrup (U.S.)
    • Tablets (U.S.)
    • Chewable tablets (U.S.)
  • Carbinoxamine and Pseudoephedrine
    • Oral solution (U.S.)
    • Syrup (U.S.)
    • Tablets (U.S.)
    • Extended-release tablets (U.S.)
  • Cetirizine and Pseudoephedrine
    • Extended-release tablets (U.S.)
  • Chlorpheniramine and Phenylephrine
    • Elixir (U.S.)
    • Oral solution (U.S.)
    • Oral suspension (U.S.)
    • Syrup (U.S.)
    • Tablets (U.S.)
    • Extended-release tablets (U.S.)
  • Chlorpheniramine, Phenyltoloxamine, and Phenylephrine
    • Extended-release capsules (U.S.)
    • Tablets (U.S.)
    • Extended-release tablets (U.S.)
  • Chlorpheniramine and Pseudoephedrine
    • Capsules (U.S.)
    • Extended-release capsules (U.S. and Canada)
    • Oral solution (U.S. and Canada)
    • Oral suspension (U.S.)
    • Syrup (U.S.)
    • Tablets (U.S.)
    • Chewable tablets (U.S.)
    • Extended-release tablets (U.S.)
  • Chlorpheniramine, Pyrilamine, and Phenylephrine
    • Oral suspension (U.S.)
    • Tablets (U.S.)
  • Dexbrompheniramine and Pseudoephedrine
    • Tablets (U.S. and Canada)
    • Extended-release tablets (U.S. and Canada)
  • Diphenhydramine and Pseudoephedrine
    • Capsules (U.S.)
    • Oral solution (U.S.)
    • Tablets (U.S. and Canada)
  • Loratadine and Pseudoephedrine
    • Extended-release tablets (U.S. and Canada)
  • Pheniramine and Phenylephrine
    • for Oral solution (Canada)
  • Promethazine and Phenylephrine
    • Syrup (U.S.)
  • Triprolidine and Pseudoephedrine
    • Syrup (U.S. and Canada)
    • Tablets (U.S. and Canada)

Brand Names

Some commonly used brand names are:

In the U.S. -

  • Allerest Maximum Strength 7
  • Allerphed 14
  • Atrohist Pediatric 7
  • Atrohist Pediatric Suspension Dye Free 8
  • Benadryl Allergy Decongestant Liquid Medication 10
  • Brofed Liquid 3
  • Bromadrine TR 3
  • Bromfed 3
  • Bromfed-PD 3
  • Bromfenex 3
  • Bromfenex PD 3
  • Chlordrine S.R. 7
  • Chlorfed A 7
  • Chlor-Trimeton 4 Hour Relief 7
  • Chlor-Trimeton 12 Hour Relief 7
  • Chlor-Trimeton Allergy-D 12 Hour 7
  • Claritin-D 12 Hour 11
  • Claritin-D 24 Hour 11
  • Colfed-A 7
  • Comhist 6
  • CP Oral 4
  • Dallergy Jr 3
  • Deconamine 7
  • Deconamine SR 7
  • Deconomed SR 7
  • Dexaphen SA 9
  • Disobrom 9
  • Disophrol Chronotabs 9
  • Drixomed 9
  • Drixoral Cold and Allergy 9
  • Ed A-Hist 5
  • Hayfebrol 7
  • Histatab Plus 5
  • Iofed 3
  • Iofed PD 3
  • Kronofed-A Jr. Kronocaps 7
  • Kronofed-A Kronocaps 7
  • Lodrane LD 3
  • Lodrane Liquid 3
  • Mooredec 4
  • Nalex-A 6
  • ND Clear T.D. 7
  • Novafed A 7
  • PediaCare Cold Formula 7
  • Poly Hist Forte 8
  • Promethazine VC 13
  • Prometh VC Plain 13
  • Pseudo-Chlor 7
  • Rescon 7
  • Rescon-ED 7
  • Rescon JR 7
  • Respahist 3
  • Rhinosyn 7
  • Rhinosyn-PD 7
  • Rinade B.I.D. 7
  • Rondamine 4
  • Rondec 4
  • Rondec Chewable 3
  • Rondec Drops 4
  • Rondec-TR 4
  • R-Tannamine 8
  • R-Tannamine Pediatric 8
  • R-Tannate 8
  • Semprex-D 1
  • Silafed 14
  • Tanafed 7
  • Trinalin Repetabs 2
  • Triotann 8
  • Triotann Pediatric 8
  • Triotann-S Pediatric 8
  • Tri-Tannate 8
  • ULTRAbrom 3
  • ULTRAbrom PD 3

In Canada -

  • Claritin Extra 11
  • Drixoral 9
  • Drixoral Night 9
  • Drixtab 9
  • Neo Citran A 12
  • Trinalin Repetabs 2
  • Vasofrinic 7

Note:

In November 2000, the Food and Drug Administration (FDA) issued a public health warning regarding phenylpropanolamine (PPA) due to the risk of hemorrhagic stroke. The FDA, supported by results of a research program, requested that manufacturers voluntarily discontinue marketing products that contain PPA and that consumers work with their healthcare providers to select alternative products.

Note:

For quick reference the following antihistamine and decongestant combinations are numbered to match the corresponding brand names.
This information applies to the following medicines:
1. Acrivastine and Pseudoephedrine (AK-ri-vas-teen and soo-doe-e-FED-rin)†
2. Azatadineand Pseudoephedrine (a-ZA-ta-deen and soo-doe-e-FED-rin)
3. Brompheniramine and Pseudoephedrine (brome-fen-EER-a-meen and soo-doe-e-FED-rin)†‡
4. Carbinoxamine and Pseudoephedrine (kar-bi-NOX-a-meen and soo-doe-e-FED-rin)†
5. Chlorpheniramine and Phenylephrine (klor-fen-EER-a-meen and fen-ill-EF-rin)†
6. Chlorpheniramine, Phenyltoloxamine, and Phenylephrine (klor-fen-EER-a-meen fen-ill-toe-LOX-a-meen and fen-ill-EF-rin)†
7. Chlorpheniramine and Pseudoephedrine (klor-fen-EER-a-meen and soo-doe-e-FED-rin)‡
8. Chlorpheniramine, Pyrilamine, and Phenylephrine (klor-fen-EER-a-meen peer-ILL-a-meen and fen-ill-EF-rin)†
9. Dexbrompheniramine and Pseudoephedrine (dex-brom-fen-EER-a-meen and soo-doe-e-FED-rin)
10. Diphenhydramine and Pseudoephedrine (dye-fen-HYE-dra-meen and soo-doe-e-FED-rin)
11. Loratadine and Pseudoephedrine (lor-AT-a-deen and soo-doe-e-FED-rin)
12. Pheniramineand Phenylephrine (fen-EER-a-meen and fen-ill-EF-rin)*
13. Promethazine and Phenylephrine (proe-METH-a-zeen and fen-ill-EF-rin)†‡
14. Triprolidine and Pseudoephedrine (trye-PROE-li-deen and soo-doe-e-FED-rin)‡
15. Cetirizine and Pseudoephedrine (trye-PROE-li-deen and soo-doe-e-FED-rin)†
* Not commercially available in the U.S.
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.

   

Next section

   

Antihistamines and Decongestants: Before Using


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