Nitisinone (Systemic)

Brand Names : Orfadin

Proper Use of This Medicine

To use :

• It is not known how nitisinone reacts with food. It is best to take it at least 1 hour before a meal.
• For small children, you may open the capsule and put the medicine in a small amount of water, formula, or applesauce. Give the medicine as soon as it is mixed.

Dosing - The dose of nitisinone will be different for different patients. Follow your doctor's orders or the directions on the label .

The number of capsules that you or your child takes depends on the strength of the medicine.

• For oral dosage form (capsules):
  • For hereditary tyrosinemia, type 1:
    • Adults - The dose is based on body weight and will be determined by your doctor. Your doctor may increase the dose as needed.
    • Children - The dose is based on body weight and will be determined by your child's doctor. Your child's doctor may increase the dose as needed.

Missed dose - If a dose of this medicine is missed, take it as soon as possible. However, if it is almost time, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage - To store this medicine:

• Keep out of the reach of children.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. heat or moisture may cause the medicine to break down.
• Store in the refrigerator. However, keep the medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.