Nitisinone (Systemic)

Brand Names : Orfadin

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with the doctor immediately if any of the following side effects occur:

More common

Bloated abdomen; dark-colored urine; dull, achy upper abdominal pain; general feeling of tiredness or weakness; headache; light-colored stools; loss of appetite; unexplained weight loss; vomiting; yellow eyes or skin

Less common

Black, tarry stools

blindness; blood in urine or stools; blisters on skin; bloody nose; blurred vision; change in color vision; chest pain or discomfort; chills; cough; darkening of urine; decreased vision; difficulty seeing at night; dry or itching eyes; dry skin; excessive tearing from eyes; eye pain; fever; fluid-filled skin blisters; general feeling of discomfort or illness; increased sensitivity of eyes to sunlight; irritation or inflammation of the eye; itching of the skin; painful or difficult urination; pinpoint red spots on skin; rash with flat lesions or small raised lesions on the skin; red, thickened, or scaly skin; redness, pain, swelling of eye, eyelid, or inner lining of eyelid burning; sensitivity to the sun; shortness of breath; skin thinness; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen and/or painful glands; unusual bleeding or bruising; unexplained nosebleed

Rare

Agitation; anxiety; back pain; bloody stools; bluish color of fingernails, lips, skin, palms, or nail beds; change in personality; change in vision; cold sweats; coma; confusion; cool, pale skin; cough producing mucus; decreased urination; diarrhea; difficulty breathing; dizziness; drowsiness; dry mouth; earache; fainting; fast heartbeat; feeling full in upper abdomen; increase in heart rate; increase in body movements; increased hunger; infection; irregular, fast or slow, or shallow breathing; irritability; lightheadedness; mood or mental changes; nausea; nervousness; pain or swelling in arms or legs without any injury; pale skin; problems with walking or talking; rapid breathing; redness or swelling in ear; seeing things that are not there; shakiness; skin rash found mostly on mucous membranes such as eyes and mouth; stiff neck; sunken eyes; thirst; tightness in chest; vomiting of blood or material that looks like coffee grounds; wheezing; wrinkled skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as the body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

Less common or rare

Absent, missed, or irregular menstrual periods; burning feeling in chest or stomach; hair loss; indigestion; sleepiness; stomach upset; stopping of menstrual bleeding; tenderness in stomach area; thinning of hair; tooth discoloration

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.